Synthetic Biology Parts, Devices and Applications
130 6 Constitutive and Regulated Promoters in Yeast 126 Shimizu‐Sato, S., Huq, E., Tepperman, J.M., and Quail, P.H. (2002) A lig ...
131 Synthetic Biology: Parts, Devices and Applications, First Edition. Edited by Christina Smolke. © 2018 Wiley-VCH Verlag GmbH ...
132 7 Splicing and Alternative Splicing Impact on Gene Design mRNA (splicing). Subsequently a complex machinery that deletes the ...
Mammals Budding yeast Exon definition Intron definition Exon ISS U2 65 35 U2AF YNYURAY UACUAAC Y(n) YAG U(n) YAG 30 nt ESE ESS G ...
134 7 Splicing and Alternative Splicing Impact on Gene Design nuclear ribonucleoprotein particles (snRNPs). Each snRNP consists ...
7.3 Splicing in east 135 present in the exon definition complex, interacting with the U2 snRNP by base pairing between the U2 a ...
136 7 Splicing and Alternative Splicing Impact on Gene Design contain introns [30]. Furthermore, the location of introns within ...
7.5 Alternative Splicing in ammals 137 the cofactor attacks the 5′ end of the intron, resulting in the first transesterifica- t ...
138 7 Splicing and Alternative Splicing Impact on Gene Design In certain cases, multiple cassette exons can be mutually exclusiv ...
7.5 Alternative Splicing in ammals 139 Hence, multiple isoforms with structural differences are produced and regu- lated during ...
140 7 Splicing and Alternative Splicing Impact on Gene Design proteins have been added based on structural and functional consid ...
7.5 Alternative Splicing in ammals 141 snRNP to the 5′ splice site. Additionally, they recruit the U2AF heterodimer and U2 snRN ...
142 7 Splicing and Alternative Splicing Impact on Gene Design It is important to note that the same splicing factors can stimula ...
7.5 Alternative Splicing in ammals 143 The kinetic model proposes that the rate of transcription elongation affects the outcome ...
144 7 Splicing and Alternative Splicing Impact on Gene Design cells, only 10% of PTC-containing genes were slightly increased in ...
7.6 Controlled Splicing in S. cerevisiae 145 alternative splicing are more frequent. Examples are mutations in TDP-43 and FUS, w ...
146 7 Splicing and Alternative Splicing Impact on Gene Design Mer1 is transcribed only during meiosis and activates splicing by ...
7.7 Splicing egulation y i ossitches 147 7.6.3 Function of Splicing in S. cerevisiae In contrast to the finding that introns see ...
148 7 Splicing and Alternative Splicing Impact on Gene Design During the last years, a plethora of different riboswitch classes ...
Bacteria (a) 5 ′ 5 ′ 3 ′ 5 ′ 3 ′ 5 ′ 3 ′ ON OFF OFF GMPc-di- GMPc-di- + +c-di-GMP +GTP +GTP +GTP ORF 3 ′ rbs ORF ss ss 3 ′ (b) ( ...
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