Science - USA (2022-06-10)
1180 10 JUNE 2022 • VOL 376 ISSUE 6598 science.org SCIENCE PHOTOS: (LEFT TO RIGHT ©VINCENT HILAIRE; KATYA TSVETKO RESEARCH | IN ...
SCIENCE science.org 10 JUNE 2022 • VOL 376 ISSUE 6598 1181 the transcription of these genes, allowing them to be expressed. Incr ...
RESEARCH ARTICLE SUMMARY ◥ NUCLEAR PORE COMPLEX Structure of the cytoplasmic ring of theXenopus laevisnuclear pore complex Xuech ...
RESEARCH ARTICLE ◥ NUCLEAR PORE COMPLEX Structure of the cytoplasmic ring of theXenopus laevisnuclear pore complex Xuechen Zhu1, ...
Nup160-CTF (Fig. 2C). The N-terminala1helices from Nup96 and Sec13 pair up to wedge into the crevice between helicesa46 anda47 o ...
featured with well-resolved side chains of a large number of bulky residues (Fig. 4A, figs. S5 and S10). Nup93-ACE1-O resides at ...
where the tail of Nup96-I contacts the crown of Nup107-O and stacks against the N-terminal a-solenoid of clamp 1 (fig. S14A, mid ...
Discussion A wealth of structural information at atomic resolution on the NPC have emerged from crystal structures of individual ...
(corresponding to segmentsa37 toa47 in the structure) of Nup160 were missing in a patient with steroid-resistant nephrotic syndr ...
geometrical restraint among subunits of the same CR and five rounds of guided multiref- erence three-dimensional classification. ...
pixel size of 2.774 Å. These particles were directly subjected to two additional rounds of two-dimensional classifications in RE ...
functional orthologs of Nup93 and the Alpha- Fold model. The EM maps also allow identifi- cation of protein-protein interfaces m ...
P. Emsley, K. Cowtan, Coot: Model-building tools for molecular graphics.Acta Crystallogr. D Biol. Crystallogr. 60 , 2126– 2132 ...
RESEARCH ARTICLE SUMMARY ◥ NUCLEAR PORE COMPLEX Architecture of the cytoplasmic face of the nuclear pore Christopher J. Bley†, S ...
RESEARCH ARTICLE ◥ NUCLEAR PORE COMPLEX Architecture of the cytoplasmic face of the nuclear pore Christopher J. Bley^1 †, Si Nie ...
Bleyet al., Science 376 , eabm9129 (2022) 10 June 2022 2of18 Fig. 1. Reconstitution of a 16-proteinC. thermophilumcomplex compos ...
therapeutic strategies for these conditions remain ill defined. Here we present insight into the atomic and higher-order archite ...
Bleyet al., Science 376 , eabm9129 (2022) 10 June 2022 4of18 Fig. 2. Conserved modular architecture and RNA-binding properties o ...
we carried out a comprehensive electrophoretic mobility shift assay (EMSA) screen to systemat- ically assess binding against a c ...
sides of the NPC in the form of distinct Ran- binding domains (RanBDs) and Zn2+-finger (ZnF) modules. On the cytoplasmic face, N ...
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