Nature - USA (2020-02-13)
Extended Data Fig. 2 | Antiproliferative activity of structurally diverse BD2 and DbBis. a, Chemical structure of A-083. b, Acti ...
Article Extended Data Fig. 3 | ABBV-744 mimics enzalutamide and ABBV-075 to block AR-dependent transcription. a, Comparison of d ...
Extended Data Fig. 4 | BD2-dependent BRD4 chromatin prof ile association with AR. a, AR peaks measured by AR ChIP–seq after trea ...
Article Extended Data Fig. 5 | BD2-dependent BRD4 binding motifs and upstream regulators. a, HOMER motifs enriched in super-enha ...
Extended Data Fig. 6 | BD2-dependent BRD4–AR interaction. a, LNCaP cells were treated for 16 h with DHT in the presence of vehic ...
Article Extended Data Fig. 7 | 22RV1 cells are resistant to ABBV-744. a, ABBV-075 but not ABBV-744 induces a robust dose-depende ...
Extended Data Fig. 8 | In vivo eff icacy and tolerability of BD2 selective inhibitors and DbBis. a, Sprague-Dawley rats (n = 3 a ...
Article Extended Data Table 1 | Data collection and refinement statistics Crystal structure coordinates and X-ray diffraction da ...
Extended Data Table 2 | Antiproliferative activities of ABBV-744 across cancer cell lines a, Segregation of ABBV-744 sensitivity ...
1 nature research | reporting summary April 2018 Corresponding author(s): Yu Shen Reporting Summary Nature Research wishes to im ...
2 nature research | reporting summary April 2018 Data Policy information about availability of data All manuscripts must include ...
3 nature research | reporting summary April 2018 Eukaryotic cell lines Policy information about cell lines Cell line source(s) T ...
Nature | Vol 578 | 13 February 2020 | 311 Article Zucchini consensus motifs determine the mechanism of pre-piRNA production Nats ...
312 | Nature | Vol 578 | 13 February 2020 Article Trimmer protein and the in vitro trimming activity (Extended Data Fig. 2d−f ). ...
Nature | Vol 578 | 13 February 2020 | 313 Fig. 3g). Type-N piRNA-2986 and 304, but not type-E piRNA-1528 and 66, have downstream ...
314 | Nature | Vol 578 | 13 February 2020 Article mitochondrial outer-membrane proteins, so we anticipated that the same strateg ...
Nature | Vol 578 | 13 February 2020 | 315 (Fig. 4b, e). The small RNAs derived from the reciprocal plasmid library that immunopr ...
316 | Nature | Vol 578 | 13 February 2020 Article which endonucleolytic mechanism they are cleaved (Extended Data Fig. 5i and Su ...
Methods Cell culture, plasmid transfection, and generation of stable or knockout cell line in BmN4 cells BmN4 cells (provided by ...
Article DNA probes were hybridized with Perfect Hyb Plus (Sigma) at 42 °C overnight. The primer sequences for genomic PCR, real- ...
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