BIOINORGANIC CHEMISTRY A Short Course Second Edition

400 IRON-CONTAINING PROTEINS AND ENZYMES TABLE 7.7 Selected Substrate/Inhibitor Contacts at Q and Q o Sites in Cytochrome bc i 1 ...

CYTOCHROME bc 1 : A BACTERIAL CYTOCHROME 401 Q Site o PDB No.(Substrate/Inhibitor) Ar - Ar or hydrophobic contacts his161 (H161) ...

402 IRON-CONTAINING PROTEINS AND ENZYMES the group included the inhibitor myxothiazol (PDB: 1SQP, resolution 2.7 Å ). Myxothiazo ...

CYTOCHROME bc 1 : A BACTERIAL CYTOCHROME 403 formed between the SMA hydroxyl group and atom O ε 1 of glu271 (O 8 (OH) · · · O ε ...

404 IRON-CONTAINING PROTEINS AND ENZYMES inhibitor NQNO (PDB: 1NUI) competes with ubiquinone for the Q i pocket and binds in the ...

CYTOCHROME bc 1 : A BACTERIAL CYTOCHROME 405 structures are the best resolved of any discussed here so far (PDB: 3BCC, resolutio ...

406 IRON-CONTAINING PROTEINS AND ENZYMES Figure 7.30 Comparison of cytochrome bc structures: (A) PDB: 1PP9 with inhibitor stigma ...

CYTOCHROME bc 1 : A BACTERIAL CYTOCHROME 407 = 2.8, H 2 O · · · H201 N ε 2 = 2.7); (3) the N ζ atom of lys227 ’ s side chain int ...

408 IRON-CONTAINING PROTEINS AND ENZYMES 7.6.6 Cytochrome bc 1 Conclusions, Overall, the conformation of the cytochrome bc 1 com ...

CYTOCHROMES c 409 In addition to the four porphyrin nitrogen ligands, cytochrome c ’ s heme iron ion carries one axial histidine ...

410 IRON-CONTAINING PROTEINS AND ENZYMES evolutionary relationships between proteins whose structure is known. It surveys protei ...

CYTOCHROMES c 411 synthesis from ADP. The bc 1 complex contains a c 1 - type cytochrome (detailed in Section 7.6) that differs f ...

412 IRON-CONTAINING PROTEINS AND ENZYMES within or within hydrogen - bonding distance of three structurally important atoms or g ...

CYTOCHROMES c 413 electronegative “ heavy ” atoms in a hydrogen - bonded pair ( dAD ) must be less than 3.4 Å ; and (3) the D – ...

414 IRON-CONTAINING PROTEINS AND ENZYMES formational changes in the two oxidation states, around the met80 ligand and in the hem ...

CYTOCHROMES c 415 molecule. As described previously, this same water molecule moves its position substantially, depending on the ...

416 IRON-CONTAINING PROTEINS AND ENZYMES transfer proteins will exhibit variations of several orders of magnitude ink 11 , depen ...

CYTOCHROMES c 417 In 1990, the Brayer group published the X - ray crystallographic structure of oxidized (Fe(III)) horse heat cy ...

418 IRON-CONTAINING PROTEINS AND ENZYMES TABLE 7.8 Selected Bonding Distances for Cytochromes c PDB No. Fe (II)/(III) (Species, ...

CYTOCHROMES c 419 PDB No. Fe (II)/(III) (Species, Crystal Space Group, Resolution Å ) H O ID 2 (watxxx) H - Bond Partner — H O D ...