BIOINORGANIC CHEMISTRY A Short Course Second Edition

360 IRON-CONTAINING PROTEINS AND ENZYMES Cytochrome researchers often cite R. P. Ambler ’ s work on classifying cyto- chromes c ...

CYTOCHROME P450 : A MONOOXYGENASE 361 in the cytochrome bc 1 complex, also known as ubiquinol : ferricytochrome c oxidoreductase ...

362 IRON-CONTAINING PROTEINS AND ENZYMES cofactors (prosthetic groups) that are intimately involved with O 2 activation. Additio ...

CYTOCHROME P450 : A MONOOXYGENASE 363 7.4.2 Cytochrome P450: Structure and Function, In this discussion, we will concentrate on ...

364 IRON-CONTAINING PROTEINS AND ENZYMES produce the ferrous species. The ferrous product is then annealed at elevated temperatu ...

CYTOCHROME P450 : A MONOOXYGENASE 365 believed to exist in many oxygenase and peroxidase catalytic cycles, is called Compound I ...

366 IRON-CONTAINING PROTEINS AND ENZYMES and other P450 reactions. The so - called “ compound I, ” a π - cation radical inter- m ...

CYTOCHROME P450 : A MONOOXYGENASE 367 that explains most mechanistic questions by invoking low - spin and high - spin states for ...

368 IRON-CONTAINING PROTEINS AND ENZYMES and water molecules in the distal pocket of their starting material, intermedi- ate ( 5 ...

CYTOCHROME P450 : A MONOOXYGENASE 369 Conclusions that the reference 48 authors take from their calculations are as follows: (1) ...

370 IRON-CONTAINING PROTEINS AND ENZYMES heme (cation radical +•) cannot be unequivocally determined from the X - ray crystallog ...

CYTOCHROME P450 : A MONOOXYGENASE 371 hydrogen bond with the hydroxyl group of thr101. Reduction by dithionite to the ferrous P4 ...

372 IRON-CONTAINING PROTEINS AND ENZYMES intermediates that they have described explain how the conserved residues asp251 and th ...

CYTOCHROME P450 : A MONOOXYGENASE 373 Fe III with the cysteine - like ligand, β - mercaptoethanol (BME) thiolate, an anionic sul ...

374 IRON-CONTAINING PROTEINS AND ENZYMES dichroism (MCD) spectrum is typical of a fi ve - coordinate thiolate - ligated ferric h ...

CYTOCHROME P450 : A MONOOXYGENASE 375 found that a [(porphyrin)Fe III (O 2 )] − complex would deformylate certain alde- hydes wh ...

376 IRON-CONTAINING PROTEINS AND ENZYMES The oxygen rebound mechanism was supported by experimental evidence including (1) high ...

CYTOCHROME P450 : A MONOOXYGENASE 377 Figure 7.21 (A) Formation of the [Fe IV = O(TMP + • )] + complex using the TMP ligand. (B) ...

378 IRON-CONTAINING PROTEINS AND ENZYMES iron(III) porphyrin complexes were found to be better catalysts in hydrocar- bon oxygen ...

CYTOCHROME P450 : A MONOOXYGENASE 379 complexes at 15 K showed a characteristic S = 3/2 spectrum with gz = 2, gy = 3.5 – 3.7, an ...