BIOINORGANIC CHEMISTRY A Short Course Second Edition

340 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS: GROUP II Wang , S. ; Karbstein , K. ; Peracchi , A. ; Beigelman , L. ; Herschl ...

Babu , Y. S. ; Bugg , C. E. ; Cook , W. J. J. Mol. Biol. , 1988 , 204 ( 1 ), 191 – 204. (PDB: 3CLN) Chattopadhyaya , R. ; Meado ...

342 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS: GROUP II Yamauchi E. ; Nakatsu T. ; Matsubara M. ; Kato H. ; Taniguchi H. Nat. ...

343 7 Bioinorganic Chemistry: A Short Course, Second Edition, by Rosette M. Roat-Malone Copyright © 2007 John Wiley & Sons, ...

344 IRON-CONTAINING PROTEINS AND ENZYMES myoglobin (Mb) and hemoglobin (Hb), is critical to the maintenance of bio- logical func ...

MYOGLOBIN AND HEMOGLOBIN 345 as well as dioxygen binding and release. (Section 2.3.4 discusses the practice and utility of site ...

346 IRON-CONTAINING PROTEINS AND ENZYMES α - helical segments (labeled A – G) and six nonhelical segments. An example of oxymyog ...

MYOGLOBIN AND HEMOGLOBIN 347 7.2.2 Structure of the Heme Prosthetic Group, Deoxymyoglobin and deoxyhemoglobin contain pentacoord ...

348 IRON-CONTAINING PROTEINS AND ENZYMES dioxygen is bound to iron on the so - called distal side of the porphyrin ring. Switchi ...

MYOGLOBIN AND HEMOGLOBIN 349 The triplet ground state (0 kJ/mol) for the O 2 molecule is represented by the term symbol^3 Σg+ an ...

350 IRON-CONTAINING PROTEINS AND ENZYMES studies confi rmed by many other instrumental and analytical techniques, a clear pictur ...

MYOGLOBIN AND HEMOGLOBIN 351 crystallographic data comparable to Mb oxyheme stereochemistry (see Table 7.1 ). In fact, the oxyge ...

352 IRON-CONTAINING PROTEINS AND ENZYMES Fe(T piv )PP - (1 - MeIm)O 2 , works better as a model for HbO 2 and MbO 2 than does mo ...

MYOGLOBIN AND HEMOGLOBIN 353 Isolation and purifi cation of the metalloprotein. For instance, Hb was fi rst crystallized in 184 ...

354 IRON-CONTAINING PROTEINS AND ENZYMES Fe II()+⇔O 22 Fe III O( )−− (7.3) Fe III O()−+ 22 −−Fe II()⇔Fe III O()− −^2 Fe III() (7 ...

MYOGLOBIN AND HEMOGLOBIN 355 (not shown in Figure 7.9B ) occupying the other, proximal side of the porphyrin ring. Design of suc ...

356 IRON-CONTAINING PROTEINS AND ENZYMES porphyrin illustrated in Figure 7.9B although many others have been synthesized.9,19 A ...

MYOGLOBIN AND HEMOGLOBIN 357 vitro preference of CO over O 2 binding to Mb and Hb are in direct confl ict with the data indicati ...

358 IRON-CONTAINING PROTEINS AND ENZYMES and Spiro studied the nanosecond dynamics of the R to T transition in hemo- globin.^25 ...

7.2.8 Conclusions, Myoglobin and hemoglobin have been studied exhaustively since chemists, biochemists, and biologists realized ...