BIOINORGANIC CHEMISTRY A Short Course Second Edition

420 IRON-CONTAINING PROTEINS AND ENZYMES The heme iron atom is 0.16 Å out of the plane formed by the four porphyrin nitrogen lig ...

CYTOCHROMES c 421 Conformational changes are found for the ferrocytochrome c hemes as well when the PDB: 1LC1 (30% ACN solution) ...

422 IRON-CONTAINING PROTEINS AND ENZYMES thioether linkages holding the cytochrome c in place appear more strained in the ferroc ...

CYTOCHROMES c 423 while the horse Har – Co – cyt c ’ s kinetics remained biphasic (see Figure 2 of reference 124 ). This result ...

424 IRON-CONTAINING PROTEINS AND ENZYMES systems immediately after dilution (concurrent with folding initiation) using NMR and c ...

CYTOCHROMES c 425 had been published on the interaction of cytochrome c with its respiratory pathway partner cytochrome c oxidas ...

426 IRON-CONTAINING PROTEINS AND ENZYMES mutant cytochrome c (cyto c) (PDB: 1S6V, resolution 1.88 Å ).^131 The higher resolution ...

CYTOCHROMES c 427 important cytochrome c conserved surface residue phe82 with tryptophan (F82W, PDB: 2B11), tyrosine (F82Y, PDB: ...

428 IRON-CONTAINING PROTEINS AND ENZYMES diseases, and neurodegenerative disorders may occur. Apoptopic events are controlled by ...

CYTOCHROME c OX IDASE 429 chrome c will tend toward the Fe(III) state, and programmed cell death will proceed. The authors propo ...

430 IRON-CONTAINING PROTEINS AND ENZYMES enzyme (Complex IV) in a sequence of membrane - bound electron transfer proteins in the ...

CYTOCHROME c OX IDASE 431 generates a transmembrane proton gradient by a different mechanism than cytochrome bc 1 (see Section 7 ...

432 IRON-CONTAINING PROTEINS AND ENZYMES cytochrome c oxidase complex, important questions include (1) the nature of the metal b ...

CYTOCHROME c OX IDASE 433 nonhelical loop region between helices VII and VIII. In its fully reduced Cu + state ( S = 0) the heme ...

434 IRON-CONTAINING PROTEINS AND ENZYMES case, a channel of polar atoms from subunits I and II amino acid side chains would guid ...

CYTOCHROME c OX IDASE 435 and tyr244 (Y244) (his240 N ε 2 – tyr244 C ε 2 = 1.35 Å ). The covalent bond would bring the tyrosine ...

Figure 7.41 (A) Two B. taurus cytochrome c oxidase molecules, (PDB: 1V54, in green, and PDB: 1V55 in cyan). Insert shows change ...

CYTOCHROME c OX IDASE 437 bring the residue ’ s side chain in contact with the intermembrane surface. The hydrogen - bonding net ...

438 IRON-CONTAINING PROTEINS AND ENZYMES In the D - pathway, water molecules and amino acid residues form a hydrogen - bonding n ...

CYTOCHROME c OX IDASE 439 The mixed valence state stores only half the electrons necessary to reduce one molecule of O 2 to wate ...