BIOINORGANIC CHEMISTRY A Short Course Second Edition

300 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS: GROUP II for the S N 2 mechanism. However, they maintain that it is still uncle ...

CALCIUM-DEPENDENT MOLECULES 301 This section has concentrated on the role of magnesium ions in catalytic RNA. Other important to ...

302 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS: GROUP II adult cardiac SR. It binds calcium with high capacity and low affi nit ...

CALCIUM-DEPENDENT MOLECULES 303 Before continuing the discussion of calmodulin ’ s properties and activities in vivo, it is impo ...

304 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS: GROUP II ser81. Calmodulin ’ s four Ca 2+ - binding domains have a typical EF h ...

CALCIUM-DEPENDENT MOLECULES 305 and B (28 – 39) shown in blue; (2) helix B to helix C connector loop (39 – 44) shown in orange; ...

306 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS: GROUP II The X - ray crystallographic structure of human calmodulin, refi ning ...

CALCIUM-DEPENDENT MOLECULES 307 that the dumbbell - shaped solution structure of all apo - calmodulins discussed here are quite ...

308 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS: GROUP II four N - terminal α - helices and exposed the hydrophobic surface as o ...

CALCIUM-DEPENDENT MOLECULES 309 TABLE 6.7 Interhelical Angles in Selected Calmodulin Structures Calmodulin Structure (Source) Me ...

310 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS: GROUP II binding sites for TFP.^81 The question arises then as to which calmodu ...

CALCIUM-DEPENDENT MOLECULES 311 bisindole - based anticancer drug molecules, vinblastine and KAR - 2 [3 ′′ - ( β - chloroethyl) ...

312 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS: GROUP II The same authors then studied the formation of ternary complexes with ...

CALCIUM-DEPENDENT MOLECULES 313 1 : 2 CaM:TFP complex was expected to form, then KAR - 2 was added, results indicated a competit ...

314 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS: GROUP II The peptides listed in Table 6.9 comprise the CaM - binding domains of ...

CALCIUM-DEPENDENT MOLECULES 315 Clore, Gronenborn, Bax, and co - workers published the three - dimensional solution structure of ...

316 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS: GROUP II peptide, a random coil in solution, becomes helical in the presence of ...

CALCIUM-DEPENDENT MOLECULES 317 tides in binding to calmodulin. It should be noted that calmodulin contains an unusually high nu ...

318 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS: GROUP II helices D and E of the central linker. As can be seen in Table 6.9 , a ...

CALCIUM-DEPENDENT MOLECULES 319 disordered and do not appear in the fi nal structural renderings (see Figure 6.27 ). Peptide N - ...