Comparative and Veterinary Pharmacology

veterinary pharmacology and therapeutics of six areas of endeavour, emphasising the potential for interaction between them: (a) ...

from disease and to generate nutritionally enhanced food, as well as for facilitating xenografting. A vast number of murine mode ...

selecting dosages which minimise its emergence. The role and importance of biofilms and quorum sensing signalling systems betwee ...

provide assurance that the impact of veterinary medicinal products and their metabolites on aquatic and terrestrial organisms (i ...

Once the use of drugs in doping has been clearly identified, there is in place a sophisticated set of procedures and principles ...

References Appelgren L-E (2009) Veterinary drugs: yesterday, today and tomorrow. J Vet Pharmacol Ther 32 (Suppl 1):7–10 Cox SP, ...

Species Differences in Pharmacokinetics and Pharmacodynamics Pierre-Louis Toutain, Aude Ferran, and Alain Bousquet-Me ́lou Conte ...

by variations in drug pharmacokinetics (PK) or drug pharmacodynamics (PD), the magnitude of which varies from drug to drug. This ...

challenge is not to select a drug but rather to determine, for the selected agent, a rational dosing regimen (involving dose rat ...

For domestic species, about 400 of the 6,000 identified breeds are of economic relevance for meat, milk, and egg production. Dog ...

certain antiparasitic agents, such as the ivermectins, and to morphine derivates, such as loperamide. The dog is the first speci ...

conclusion holds for birds (Hunter et al. 2008 ). For a review including applications to veterinary species, see Mahmood ( 2005 ...

Oral administration is the most natural route of drug administration and there are many examples of interspecies differences in ...

the latter purpose, the oral route is chosen because only this oral route enables large numbers of animals (sometime several tho ...

main cause of observed inter-species differences and the veterinary literature is regularly enriched with new examples. Species ...

In contrast with interspecies differences in PK, examples of PD interspecies differences are less numerous and not so well docum ...

between the epithelial cells, while thiscondition does not exist in stallions or in bulls. Xylazine, an alpha2-adrenergic agonis ...

5 Origin of Interspecies Differences in Dosage Regimens For each drug in each species an efficacious and safe dosage regimen (do ...

covering a wide range of MW (150 to>700) demonstrated an increase in the proportion of compounds excreted in the bile vs. uri ...

should be 10 times higher in donkeys. Similarly, PK data indicate that plasma clearance is higher in the donkey than in the hors ...