Novel Chemical Tools to Study Ion Channel Biology (Advances in Experimental Medicine and Biology)
94 K. Mruk and W. R. Kobertz linker (Fig. 5b). Because CTX binds to the redesigned KCNQ1 channels with high affinity, at nanomol ...
95 KCNE β subunits. By subtracting the inhibited current traces from the pre-treated traces, a hierarchy of KCNE modulation of K ...
96 K. Mruk and W. R. Kobertz dent channel ligand, an acrylamide electrophile, and the photocleavable chromo- phore, nitroindolin ...
97 Chabala LD, Lester HA (1986) Activation of acetylcholine receptor channels by covalently bound agonists in cultured rat myoba ...
98 K. Mruk and W. R. Kobertz Karpen JW, Brown RL (1996) Covalent activation of retinal rod cGMP-gated channels reveals a functio ...
99 Morin TJ, Kobertz WR (2008b) Tethering chemistry and K + channels. J Biol Chem 283(37):25105– doi:R800033200 [pii] 10.1074/j ...
100 K. Mruk and W. R. Kobertz Wang S, Szobota S, Wang Y, Volgraf M, Liu Z, Sun C, Trauner D, Isacoff EY, Zhang X (2007) All opti ...
101 H. Janovjak () · C. K. McKenzie · I. Sanchez-Romero Institute of Science and Technology Austria, Am Campus 1, A-3400, Klost ...
102 C. K. McKenzie et al. 1 Introduction In all domains of life optical cues control essential physiological and behavioural pro ...
Flipping the Photoswitch: Ion Channels Under Light Control 103 coined the term photochromism (Hirshberg 1950 ). In common photoc ...
104 C. K. McKenzie et al. planar and purple coloured merocyanines (MCs) using UV light that breaks the spiro-carbon-oxygen bond ...
Flipping the Photoswitch: Ion Channels Under Light Control 105 Fig. 2 Main classes of photochromic ion channel controllers. a In ...
106 C. K. McKenzie et al. 3.2 PTLs: Ligands-on-a-Leash In contrast to PCLs, PTLs target genetically modified ion channels throug ...
Flipping the Photoswitch: Ion Channels Under Light Control 107 control of ion channel function, further design and application o ...
108 C. K. McKenzie et al. incorporating the phenol of propofol into the photochrome (Figs. 2 and 3 ). Both PCLs potentiate GABAA ...
Flipping the Photoswitch: Ion Channels Under Light Control 109 capable of restoring functional light sensitivity in rat retinas ...
110 C. K. McKenzie et al. channels with this ‘sign inversion’ allows experimenters to target two separate neu- ronal populations ...
Flipping the Photoswitch: Ion Channels Under Light Control 111 strategy’ using photoswitchable conditional subunits (PCS) (Sando ...
112 C. K. McKenzie et al. 5 Outlook By combining chemical synthesis, photophysics and biophysics, the fields of photo- pharmacol ...
Flipping the Photoswitch: Ion Channels Under Light Control 113 Tochitsky et al. 2014 ; Caporale et al. 2011 ), and the identific ...
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