Artemisinin and Nitric Oxide Mechanisms and Implications in Disease and Health

123 SPRINGER BRIEFS IN MOLECULAR SCIENCE Qing-Ping Zeng Artemisinin and Nitric Oxide Mechanisms and Implications in Disease and ...

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Qing-Ping Zeng 1 3 Artemisinin and Nitric Oxide Mechanisms and Implications in Disease and Health ...

Qing-Ping Zeng Tropical Medicine Institute Guangzhou University of Chinese Medicine Guangzhou China ISSN 2191-5407 ISSN 2191-541 ...

v Nitric oxide (NO), a physiologically important signaling molecule, was proclaimed “a molecule of the year” in 1992 by the Scie ...

vi Preface developing insulin resistance, type II diabetes, fatty liver, and even liver cancer because his/her iNOS is always ac ...

vii Acknowledgments I wish to thank all my colleagues and graduate students in the Laboratory of Biotechnology, Tropical Medicin ...

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7.1 Nitrosylation/Nitration in the Active Center More information about this series at http://www.springer.com/series/ 1 Backgr ...

xiii Abbreviations 3NT 3-Nitrotyrosine AMP Ampicillin AMPK Adenosine monophosphate-activated protein kinase ARG l-arginine ASC A ...

xiv Abbreviations G+ Gram-positive bacteria GAPDH Glyceraldehyde-3-phosphate dehydrogenase GC Gualylate cyclase GLUT Glucose tra ...

Abbreviations xv SOD Superoxide dismutase SpO 2 Saturation percentages of O 2 TERT Telomerase reverse transcriptase TLR4 Toll-li ...

1 Abstract ART has been found, for the first time, to alkylate the heme-containing enzymes (hemoenzymes) by covalently conjugati ...

2 1 Background In recent years, we revealed that ART can mimic CR to extend yeast lifespan and compromise mouse telomere shorten ...

3 of ART to heme, a process known as heme alkylation, was first observed by Meshnick et al. ( 1991 ), who identified the ART-hem ...

4 1 Background Considering the evolutionary conservation of NO signaling among organisms, we assumed that NO may also protect tu ...

5 whole body weight, and lead to the recovery of a raised serum insulin level to the normal one seen in the control. The prelimi ...

6 1 Background is widely accepted that lifespan is determined by an individual genetic background and multiple environmental fac ...