Artemisinin and Nitric Oxide Mechanisms and Implications in Disease and Health

90 6 ART for Antiaging 6.2.2.8 Covalent ART-Heme Conjugation and Synchronous COX Induction Until currently, no direct evidence i ...

91 deficiency during CR. However, this is an apparent paradoxical phenomenon for CR because glucose supply is restricted during ...

92 6 ART for Antiaging In the context of signaling, it is clear that AMPK (encoded by Snf1 in yeast) and SIRT1 (encoded by Sir2 ...

93 A correlation of enhanced respiration by potent antioxidation as one of the mechanisms of longevity is established in yeast, ...

94 6 ART for Antiaging CR exerts a role in yeast lifespan extension experiencing two stages: the one is enhanced antioxidation t ...

95 cellular aging of somatic cells, especially in blood white cells. A longer telomere may reflect less DNA damage and more chro ...

96 6 ART for Antiaging activator SIRT3. ARG leads to the highest Mn-SOD activity, suggesting a syner- gistic manner of antioxida ...

97 6.3.2.3 Predisposition of Downregulation of DNA Repair Genes on Compromise of Telomere Shortening We found CR keeps longer te ...

98 6 ART for Antiaging noticed that ART, SNP, or ARG can lead to the upregulation of mitochondrial bio- markers, such as mitofus ...

99 These results unambiguously indicated that CR and mimetics can produce NO, drive mitochondrial biogenesis, and recover energy ...

100 6 ART for Antiaging that mitochondrial uncoupling-elicited increases of AMP/ATP and NAD+/NADH ratios can separately activate ...

101 to increase longevity in nematodes by triggering the response to ROS (Yang and Hekimi 2010 ). Moreover, H 2 O 2 -induced ant ...

102 6 ART for Antiaging After treatment by CR mimetics for 6 h, we determined an elevated ATP level in mouse skeletal muscles, w ...

103 downregulation of protein turnover-relevant ubiquitylation pathway genes, includ- ing DNA repair-responsible tumor suppresso ...

104 6 ART for Antiaging Cerqueira FM, Laurindo FRM, Kowaltowski AJ (2011) Mild mitochondrial uncoupling and calo- rie restrictio ...

105 Hewitt G, Jurk D, Marques FDM, Correia-Melo C, Hardy T, Gackowska A, Anderson R, Taschuk M, Mann J, Passos JF (2012) Telomer ...

106 6 ART for Antiaging Lin SJ, Defossez PA, Guarente L (2000) Requirement of NAD and SIR2 for life-span extension by CR in Sacc ...

107 Piper PW, Harris NL, MacLean M (2006) Preadaptation to efficient respiratory maintenance is essential both for maximal longe ...

108 6 ART for Antiaging Vera E, Bernardes de Jesus B, Foronda M, Flores JM, Blasco MA (2013) Telomerase reverse transcriptase sy ...

109 Abstract The exact mechanisms behind aging-related diseases remain unknown. Oxidative/nitrosative stress-mediated posttransl ...