Artemisinin and Nitric Oxide Mechanisms and Implications in Disease and Health

27 Mason MG, Nicholls P, Wilson MT, Cooper CE (2006) Nitric oxide inhibition of respiration involves both competitive (heme) and ...

28 2 NO and ART van Wonderen JH, Burlat B, Richardson DJ, Cheesman MR, Butt JN (2008) The nitric oxide reductase activity of cyt ...

29 Abstract ART acts on tumor cells differentially by the threshold concentrations. High-dose ART kills tumor cells upon the inh ...

30 3 ART for Antitumor proposed (Kwok and Richardson 2002 ). Tumor cells in exposure to ART were found to exhibit a correlation ...

31 preferential mediator for antitumor, and hemoproteins should be ART’s targets in tumor cells. Validation of such a suggested ...

32 3 ART for Antitumor that the survival rate of tumor cells is highly dependent upon ART’s concentra- tions, in which 50 μM ART ...

33 3.2.3 Discussion It has been reported that approximately 5–18 % of ART can bind to hemoproteins such as hemoglobin, but does ...

34 3 ART for Antitumor evident by monitoring the shift of absorbance from heme (A 415 ) to ART-heme adducts (A 476 ). Accordingl ...

35 3.3.2 Results and Analysis 3.3.2.1 In Vitro Evaluation of ASC on Tumor Cell Proliferation The optimal dosages of all componen ...

36 3 ART for Antitumor Table 3.2 Sensitization of ART’s antitumor activity by ASC when evaluated in tumor-bearing nude mice A si ...

37 In the ASC group, CAT activity from 50 U/mg of total proteins in the control drops to 5 U/mg of total proteins as tested afte ...

38 3 ART for Antitumor inhibit CAT, but not other antioxidant enzymes. In the present study, we found that ART can significantly ...

39 Efferth T (2005) Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy. Drug Resist Updates 8:85–97 Efferth T ( ...

41 Abstract In Gram positive bacteria, bNOS-derived NO confers the protection of bacteria from environmental stress such as anti ...

42 4 ART for Antibacterial Infection in 1990. Recently, a new antibiotic resistant gene, bla (^) NDM-1, that exists in a plas- m ...

43 antibacteria role. Here, we report that ART can serve as a novel bNOS inhibitor to synergize antibiotics for more effective a ...

44 4 ART for Antibacterial Infection These results indicated that bacteria can synthesize NO for adaptation to oxi- dative stres ...

45 (20 μg/ml) is as threefold as that in bacteria treated by RIF (20 μg/ml) + ART (60 μg/ml). It means that enhanced H 2 O 2 pro ...

46 4 ART for Antibacterial Infection 5.2.3 Discussion The nonpathogenic B. subtilis and pathogenic B. anthracis as well as other ...

47 It can be concluded that ART facilitates the bactericidal effect of antibiotics by synchronously inactivating bNOS and CAT, w ...