Artemisinin and Nitric Oxide Mechanisms and Implications in Disease and Health

7 This theory defines why NO has dual impacts on cells and organisms. An opti- mal level of NO that triggers tolerable doses of ...

8 1 Background POX. An appropriate level of NO, therefore, allows the induction of antioxidant enzymes for ROS scavenging, which ...

9 burst, ROS activate antioxidative responses, and antioxidation alleviates oxidative stress. In similar, mitochondrial uncouple ...

10 1 Background We are very confident to conclude that ROS should be reversely correlated with lifespan, i.e., a higher level of ...

11 Forstermann U (2010) Uncoupling of endothelial NOS in cardiovascular disease and its phar- macological reversal. In: Ignarro ...

12 1 Background Vera E, Bernardes de Jesus B, Foronda M, Flores JM, Blasco MA (2013) Telomerase reverse transcriptase synergizes ...

13 Abstract NO, mainly synthesized by NOS, is a signal transducer that conveys internal and external stimulations. The isoform o ...

14 2 NO and ART from ARG by various NOS (Liu and Gross 1996 ). Although NO production is also evident in plants, yeast, and G− b ...

15 homology with mammalian NOS was confirmed, but no reductase domain identi- fied (Gusarov et al. 2008 ). Later, an alternative ...

16 2 NO and ART generator for controlling vascular tone, insulin secretion, and airway function, in particular, being involving ...

17 S-nitrosylation of cysteine and 3-nitration of tyrosine are two major types of post- translational modifications of many prot ...

18 2 NO and ART analysis by nuclear magnetic resonance, mass spectroscopy, and X-ray crystal dif- fraction, ART was eventually c ...

19 transgenic A. annua L. plants using the integrated genetic engineering strategies of “opening carbon flux” toward ART and “cl ...

20 2 NO and ART natural cellular environment to enable an accelerated accumulation of ART. Those achievements should pave a wide ...

21 animals, but no mutagenic and teratogenic roles of ART were found in malaria- infected pregnant women. 2.2.4 The Plausible Me ...

22 2 NO and ART 2.3 Interactions of Heme with NO and ART GC is a major receptor for NO binding, by which the enzyme is activated ...

23 hence converting one molecule of O 2 to two molecules of H 2 O. Additionally, COX translocates four protons across the mitoch ...

24 2 NO and ART Studies with totally synthetic trioxolanes and tetraoxanes support the alkylation of heme identified by mass spe ...

25 Balsa E, Marco R, Perales-Clemente E, Szklarczyk R, Calvo E, Landázuri MO, Enríquez JA (2012) NDUFA4 is a subunit of complex ...

26 2 NO and ART del Pilar Crespo M, Avery TD, Hanssen E, Fox E, Robindon TV, Valente P, Taylor DK, Tilley L (2008) Artemisinin a ...