Nucleic Acids in Chemistry and Biology

10.6 DNA Packaging 10.6.1 Nucleosomes and Chromatin of the Eukaryotes A typical eukaryotic cell contains roughly 2 metres of DNA ...

The nucleosomal histones contact the DNA through
-helices and loops. Some of the long
-helices are oriented so that their heli ...

410 Chapter 10 Figure 10.16 (a) A composite of DNA packaging proteins from the three domains of life. Comparison of the archaeal ...

Protein–Nucleic Acid Interactions 411 Figure 10.17 Representative bacterial DNA polymerases. (a) T7 bacteriophage DNA polymerase ...

initiates the synthesis of short RNA fragments (Section 6.6, Figure 6.17). Often the initiation is an abortive ‘futile’ cycle in ...

Protein–Nucleic Acid Interactions 413 with pyrophosphate that is released during the extension reaction. Thus, the RNA polymeras ...

414 Chapter 10 α α α ADP +Pi ADP +Pi Empty γ F1-ATPase NDP +Pi NDP +Pi NTP NTP Empty Empty Helicase DNA a b Figure 10.19 The str ...

at its narrowest point of 36 Å, which is large enough to accommodate the duplex DNA. The negative charge of the ring might elect ...

RecA. Perhaps, like the T7 ring helicase, the DNA conjugation pump might undergo asymmetric changes within the ring, so that two ...

Protein–Nucleic Acid Interactions 417 10.9.1 Single-Stranded RNA Recognition Here, we describe only a few, representative RNA/pr ...

418 Chapter 10 Figure 10.21 RNA-binding rings in all three taxonomic domains of life. (a) The trp RNA-binding attenuation protei ...

All tRNAs have the same general shape, resembling the letter ‘L’, and all have a CCA sequence at the 3 terminus that serves as ...

(Figure 10.23a). This Class I synthetase binds on one side of the tRNA and contacts the sugar–phosphate backbone and the minor g ...

extra loop of seryl-tRNA is recognized by the enzyme, but not the anticodon loop. A conserved N-terminal domain of the protein f ...

An interactive website with details of the classification taxonomy for DNA-binding motifs can be found at the address: http://ww ...

G.B. Koudelka, S.C. Harrison and M. Ptashne, Effect of non-contacted bases on the affinity of 434 operator for 434 repressor an ...

M.R. Singleton and D.B. Wigley, Multiple roles for ATP hydrolysis in nucleic acid modifying enzymes. EMBO J., 2003, 22 , 4579–4 ...

I. Toro, S. Thore, C. Mayer, J. Basquin, B. Seraphin and D. Suck, RNA binding in an Sm core domain: X-ray structure and functio ...

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CHAPTER 11 Physical and Structural Techniques Applied to Nucleic Acids CONTENTS 11.1 Spectroscopic Techniques 428 11.1.1 Ultravi ...