Nucleic Acids in Chemistry and Biology

dihydrodiol epoxide of 3-methylcholanthreneappears to be too bulky to intercalate into DNA. Work at the National Institutes of H ...

A group of ‘second generation’anti-cancer agentshas emerged, many of which are natural products, but now augmented by a growing ...

of DNA and RNA, but many of them have also shown useful anti-tumour activity, which must arise from selective toxicity. This can ...

Robert Coleman has shown that initial alkylation is at N-7 of a dG residue involving the aziridine ring C-10 (Figure 8.23a). It ...

problems for DNA repair systems (Section 8.11). Tomaymycinhas been shown to induce greater confor- mational changes, namely heli ...

8.7.3 Enediyne Antibiotics A range of clinically significant anti-cancer drugs can mediate oxygen-dependent cleavageof the ribos ...

chemistry and medicine since this group of compounds contains some of the most potent anti-tumour antibiotics known. They are ab ...

ethoxyacrylyl-anthranilate moiety with downstream minor groove binding of a trisaccharide unit (Figure 8.27b).^60 Hydrogen atom ...

8.7.4 Antibiotics Generating Superoxide Tetrazomineis a secondary metabolite that is a member of the quinocarcin/saframycin clas ...

The stereochemistry of these [22] cyclobutane dimers requires that Py<>Py formation in native DNA is predominantly an int ...

The structure of a DNA decamer containing a (6-4) adduct has been determined by NMR analysis.^69 Because (6-4) adducts are highl ...

It results from (i) a combination of the relative yields for their photochemical formation (approx. 100:25:1), (ii) the capabili ...

impaired by the presence of the third DNA strand.^74 Such psoralen-oligonucleotide conjugates are probes for sequence-specific h ...

8.8.4 DNA and the Ozone Barrier Life is shielded from DNA-damaging solar radiation by the ozone layer.77,78The amount of ozone i ...

Agency for Research on Cancer has estimated that every year, between two and three million new cases of non-malignant melanomas ...

8.10 Biological Consequences of DNA Alkylation DNA damage is unavoidable and can be divided broadly into two categories. Some fo ...

the glycosylic bond of a 7-alkylguanine residue undergoes slow and spontaneous hydrolysis, and so creates an apurinic site. This ...

8.10.2 O-Alkylated Lesions O^6 -Alkylguanines are locked in the enol-tautomericform while guanine in DNA is normally in the keto ...

in mammals.^90 The various types of DNA repair will be considered in order of increasing molecular com- plexity, with primary em ...

Escherichia colihas two methyltransferases, an inducible Ada protein that demethylates mainly O^6 - MeG while the constitutive O ...