Nucleic Acids in Chemistry and Biology

planar to the benzimidazole ring to which it is attached. The O-4 atoms of the deoxyribose sugar of the DNA backbone are in the ...

and H
17.6 kJ mol^1 at 30.1°C). The binding-induced change in heat capacity ( Cp) is therefore estimated as 1.38 kJ mol^1 K^1. ...

From evaluation of Cpone can calculate the possible contribution to binding free energy that arises from the hydrophobic transfe ...

groups suggests that these compounds should bind in the minor groove. However, solution studies, (NMR, LD and DNA unwinding) hav ...

The conclusion is that for all drug–DNA interactions, intercalation and groove binding represent two potential low-energy wells ...

inherent specificity of base–base interactions, triplex formation is a versatile and powerful tool for sequence- specific recogn ...

In recent years a number of triple helix-specific ligandshave been characterized (Figure 9.20). The func- tion of such ligands i ...

Most strategies aimed at triplex stabilization have centred on intercalators, which can also bind to duplex DNA as well as to tr ...

the replicative life span of most somatic cells to about 50 rounds of mitosis. Germline cells, proliferative stem cells, and tum ...

One of the most important factors that influences folding topology is the type of monovalent cation present during folding. For ...

NMR, and ITC have all shown that TMPyP4 does indeed stabilize both parallel and antiparallel quadru- plex DNA. In addition, this ...

presence of two positive charges on the ligand undoubtedly enhances quadruplex binding. PIPER also exhibits significant antitelo ...

R.E. Dickerson, H.R. Drew, B.N. Conner, R.M. Wing, A.V. Fratini and M.L. Kopka, The anatomy of A-, B- and Z-DNA. Science, 1982, ...

D. Rentzeperis and L.A. Marky, Interaction of minor groove ligands to an AAATT/AATTT site: cor- relation of thermodynamic chara ...

H. Han and L.H. Hurley, G-quadruplex DNA: a potential target for anticancer drug design. Trends Pharm. Sci., 2000, 21 , 136–142 ...

CHAPTER 10 Protein–Nucleic Acid Interactions CONTENTS 10.1 Features of DNA Recognized by Proteins 384 10.2 The Physical Chemistr ...

10.7 Polymerases 409 10.7.1 DNA-Directed DNA Polymerases 409 10.7.2 DNA-Directed RNA Polymerases 410 8Machines that Manipulate ...

partially neutralize the DNA charges and therefore contribute to duplex stability. These counter-ions are displaced when the com ...

In the idealized A-form of duplex DNA, the major and minor grooves are more equal in width (Figure 10.1a). The major groove of t ...

A-form DNA (Figure 10.1a). These duplexes may be recognized more by shape and groove width than by specific hydrogen-bonding con ...