Nucleic Acids in Chemistry and Biology

288 Chapter 7 O Ade -1 O O V RO O Gua +1 O OH O P OR O O O O N N N N O N N N N N N H H N N N N N H H H A 9 G 8 A 38 3.2Å 3.0Å 3. ...

RNA Structure and Function 289 Figure 7.41 The secondary and tertiary structures of pseudoknots. (a) Many RNA molecules contain ...

References K. Chin, K. Sharp, B. Honig and A.M. Pyle, Calculating the electrostatic properties of RNA provides new insights int ...

G.J. Quigley, F.L. Suddath, A. McPherson, J.J. Kim, D. Sneden and A. Rich, The molecular structure of yeast phenylalanine trans ...

P.F. Agris, Decoding the genome: a modified view, Nucleic Acids Res., 2004, 32 , 223–238. T. Muramatsu, K. Nishikawa, F. Nemoto ...

J.C. Penedo, T.J. Wilson, S.D. Hayasena, A. Khvorova and D.M.J. Lilley, Folding of the natural hammerhead ribozyme is enhanced ...

http://www.ebook3000.com ...

CHAPTER 8 Covalent Interactions of Nucleic Acids with Small Molecules and Their Repair CONTENTS 8.1 Hydrolysis of Nucleosides, N ...

8.11 DNA Repair 325 8.11.1 Direct Reversal of Damage 326 8.11.2 Base Excision Repair of Altered Residues 328 8.11.3 Mechanisms a ...

Reduction of ribonucleosides directly to 2
-deoxyribonucleosides can be accomplished by one of the several Barton procedures inv ...

(Figure 8.3). Such procedures have frequently been adopted to make the 3
-terminus of an oligonucleotide inert to 3
-exonuclease ...

8-azidopurine nucleosides for use as photoaffinity labels).^15 It is much more difficult to control the use of ele- mental fluor ...

8.5.2 Reactions with Nitrogen Electrophiles The standard reaction of nitrousacid (as NO) in the deaminationof primary amines co ...

8.5.3.2 Alkylating Agents. Twelve of the nitrogen and oxygen residues of the four nucleic acid bases, in addition to the phospha ...

7-methyl-2
-deoxyguanosine residue, treatment of the oligonucleotide with 1M piperidine at 90°C for 30min leads to opening of th ...

Intensive development of platinum complexes has identified several analogues of clinical potential including cis-trans-cis-ammin ...

8.6.1 Aromatic Nitrogen Compounds Investigations of the binding of N-aryl carcinogens to nucleic acids began in the 1890s with a ...

Covalent Interactions of Nucleic Acids with Small Molecules and Their Repair 305 NHAc N Ac OH NOC 6 H 11 O 6 Ac NHAc N Ac OSO 3 ...

and identified and are formally derived from a hypothetical nitrenium ion.^34 This, as an ambident cation, bonds either from nit ...

be carcinogenic in animals and lead to methylation, ethylation, or propylation of DNA, as described above (Section 8.5.3).^21 8. ...