Nucleic Acids in Chemistry and Biology

8.11.2 Base Excision Repair of Altered Residues In mammalian cells, excision repairis the most important mechanism and involves ...

double-stranded oligonucleotide (Table 8.1). The human enzyme MUTYH appears to be homologous to the bacterial repair glycosylase ...

extent of helical distortion resulting from the lesion. Nucleotide excision repair appears to be the domin- ant type of repair p ...

MMR. This repair has to deal with mismatches between the four regular bases, by modified bases, and especially by nucleotide ins ...

complex and the excision repair enzymes.^109 For example, 70% of photodimers in an active DHFRgene in Chinese hamster ovary cell ...

dimer lesion. First, in the case of the lesion T<>T, pol I is able to bypass the dimer and incorporates adenines opposite ...

References W. Szybalski, Effects of elevated temperatures on DNA and on some polynucleotides. Denaturation, renaturation, and c ...

between sulfur mustard and DNA of calf thymus and human blood. Chem. Res. Toxicol., 1994, 7 , 199–204. F.P. Guengerich, S. Lang ...

E.S. Newlands, M.F.G. Stevens, S.R. Wedge, R.T. Wheelhouse and C. Brock, Temozolomide: a review of its discovery, chemical prop ...

J.D. Scott and R.M. Williams, Chemistry and biology of the tetrahydroisoquinoline antitumor antibi- otics. Chem. Rev., 2002, 10 ...

T.E. Spratt and D.E. Levy, Structure of the hydrogen bonding complex of O6-methylguanine with cytosine and thymine during DNA r ...

G.C. Walker, SOS-regulated proteins in translesion DNA synthesis and mutagenesis. Trends Biochem. Sci., 1995, 20 , 416–420. M.F ...

http://www.ebook3000.com ...

CHAPTER 9 Reversible Small Molecule–Nucleic Acid Interactions CONTENTS 9.1 Introduction 342 9.2 Binding Modes and Sites of Inter ...

9.1 Introduction Most biological processes are reliant upon molecular recognition and the reversible interactions of one set of ...

form intramolecular folds with regions of duplex, internal loops, bulges and hairpins, for example, in ribo- somes, tRNA, or gen ...

increase in binding affinity for cationic ligands as bulk salt concentration is decreased. Hence both the melt- ing temperature ...

(9.7) and (9.8) where ln KTand the corresponding free energy term GTrefer to a standard state of [MX] of 1 M Gpeis the polyelect ...

mechanism of action is unknown. However, it is likely that polyamines play an analogous role to histones in that they may neutra ...

Crystallographic studies have also shown that minor groove widthis instrumental in dictating hydration pat- terns.The duplex d(C ...