Nucleic Acids in Chemistry and Biology
energies available from the environment. So, for example, the intrinsic free energy difference between Z- and B-forms is close t ...
As the DNA winds around the nucleosome core, the major and minor grooves are compressed on the inside with complementary widenin ...
shows loops of anti-parallel -sheets inserted into the DNA minor groove (Section 10.6.2, Figure 10.16b) in non-sequence specifi ...
relatively complex tertiary structure had been revealed was transfer RNA. Then came the structures of ribozymes and those of num ...
References C. Altona and M. Sundaralingam, Conformational analysis of the sugar ring in nucleosides and nucleotides. A new desc ...
Y. Timsit and D. Moras, Cruciform structures and functions. Quart. Rev. Biophys., 1996, 29 , 279–307. D.M. Lilley, K.M. Sulliva ...
Y.S. Sanghvi and P.D. Cook (eds), Carbohydrate modifications in antisense research. ACS Symp. Ser., Vol. 580, American Chemical ...
D.T. Nair, R.E. Johnson, S. Prakash, L. Prakash and A.K. Aggarwal, Replication by human DNA polymerase occurs by Hoogsteen base ...
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CHAPTER 3 Nucleosides and Nucleotides CONTENTS 3.1 Chemical Synthesis of Nucleosides 77 3.1.1 Formation of the Glycosylic Bond 7 ...
antisense technologies (Section 5.7.1),^1 studying RNA and DNA structure,2,3DNA–protein interactions (Chapter 10) and nucleic ac ...
sugar moiety. Third, a double disconnection C shows the formation of a purine base onto a preformed imi- dazole ribonucleoside. ...
the desired thermodynamic products at N-9 for purines and N-1 for pyrimidines, the condensation reactions are often mechanistica ...
a catalyst gave way to Lewis acid catalysts^19 (e.g.SnCl 4 or Hg(OAc) 2 ) and they, in turn, have been super- seded by the use o ...
The synthetic methodology for the preparation of nucleosides using Lewis acid catalysts, most com- monly, trimethylsilyl triflat ...
from one base to another by a process known as transglycosylation.28–30This procedure makes use of the fact that nucleoside form ...
This reaction has all the hallmarks of an SN1 ionization process, as shown both by the intramolecular transfer of a sugar residu ...
face to give the natural -anomer (Baker’s 1,2-trans-rule). While the formation of the acyloxonium inter- mediate ensures good s ...
good yields of the corresponding 2-deoxyribonucleoside with the natural -configuration.^42 The useful stereocontrol achieved i ...
3.1.2 Building the Base onto a C-1 Substituent of the Sugar This approach^49 to nucleoside synthesis has three important feature ...
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