Nucleic Acids in Chemistry and Biology
Although aminopterin was the first clinically useful folate, methotrexate was soon introduced in therapy and it has become the m ...
Other important alkylating agents used in cancer treatment include the nitrosoureas carmustine (BCNU) and lomustine (CCNU) which ...
at the growing 3-end, this moiety cannot become phosphorylated by the next dNTP monomer. One of the first compounds to be widel ...
steps within the infected cell. Sometimes a non-specific enzyme (e.g.pyruvate kinase) can perform this task. Mammalian cellular ...
Large randomized and cohort studies on asymptomatic patients have demonstrated that non-nucleoside reverse-transcriptase inhibit ...
viral infections, such as HIV. For example, the anti-AIDS drug AZT (Figure 3.90) was marketed within a year of the report of its ...
The inconvenience of the need to administer this drug intravenously for CMV infections can also be over- come by using the L-val ...
because the nucleoside is a substrate for the viral thymidine kinasebut not for the host-cell TK. This viral thymidine kinase is ...
dehydrogenase, resulting in a depletion of cellular GTP pools. This in turn means that ribavirin 5-triphosphate is an effective ...
J.J. Fox, N. Yung, I. Wempen and J. Doerr, Pyrimidine nucleosides III. On the synthesis of cytidine and related pyrimidine nucl ...
J.R. Hanrahan and D.W. Hutchinson, The enzymatic-synthesis of antiviral agents. J. Biotechnol., 1992, 23 , 193–210. D.W. Hutchi ...
S. Ohira, T. Sawamoto and M. Yamato, Synthesis of ()-neplanocin-a viaC H insertion of alkyli- denecarbene. Tetrahedron Lett., ...
D.B. Olsen, F. Benseler, H. Aurup, W.A. Pieken and F. Eckstein, Study of a hammerhead ribozyme containing 2-modified adenosine ...
V.J. Davisson, D.R. Davis, V.M. Dixit and C.D. Poulter, Synthesis of nucleotide 5-diphosphates from 5-O-tosyl nucleosides. J. ...
S. Miura and S. Izuta, DNA polymerases as targets of anticancer nucleosides. Curr. Drug Targets, 2004, 5 , 191–195. I.M. Kompis ...
CHAPTER 4 Synthesis of Oligonucleotides CONTENTS 4.1 Synthesis of Oligodeoxyribonucleotides 143 4.1.1 Overall Strategy for Chemi ...
144 Chapter 4 4.1.1 Overall Strategy for Chemical Synthesis Nucleic acids are sensitive to a wide range of chemical reactions (s ...
Synthesis of Oligonucleotides 145 nucleoside attached to a solid support. Since the 5-hydroxyl group is a more effective nucleo ...
146 Chapter 4 synthesis with either dichloroacetic acid or trichloroacetic acid in non-aqueous solvent, conditions that prevent ...
Synthesis of Oligonucleotides 147 with 2-chlorophenyl phosphoro-bis(triazolide) (Figure 4.5, Route a). Despite this being a bifu ...
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