Organ Regeneration Based on Developmental Biology

233 Ishikawa M, Sekine K, Okamura A et al (2011) Reconstitution of hepatic tissue architectures from fetal liver cells obtained ...

234 Oshima M, Inoue K, Nakajima K et al (2014) Functional tooth restoration by next-generation bio- hybrid implant as a bio-hybr ...

235 Toyohara T, Mae S, Sueta S et al (2015) Cell therapy using human induced pluripotent stem cell- derived renal progenitors Am ...

© Springer Nature Singapore Pte Ltd. 2017 237 T. Tsuji (ed.), Organ Regeneration Based on Developmental Biology, DOI 10.1007/978 ...

238 13.1 Introduction Degenerative lung diseases, such as COPD and pulmonary fibrosis, are both com- mon and a major cause of mo ...

239 current time. While the ability to efficiently derive certain cell types and tissues, such as hepatic or neuronal cells, in  ...

240 the anterior primitive streak, exposure of PSCs to high levels of activin A, a Nodal analogue that acts through the same rec ...

2 41 13.4 Specification of Lung Progenitors The endoderm of the primitive foregut develops organ-specific domains represent- ing ...

242 including separation of the trachea and esophagus, branching morphogenesis, and differentiation of lung epithelium (Kimura e ...

243 DE described above, cells are sequentially exposed to factors promoting first ante- riorization and then ventralization. Ant ...

244 The high levels of Shh expression at the distal lung bud tip induce expression of hedgehog-interacting protein (Hhip) in the ...

245 13.6 3D Functional Organization of In Vitro Derived Lung Lineages As discussed in the previous section, there has been consi ...

246 demonstrated that there are important differences in ECM composition of decellu- larized lung tissue from donors with idiopa ...

247 (Daly et al. 2012 ; Wallis et al. 2012 ). In this technology, decellularized lungs (most commonly of murine origin) are rece ...

248 et al. 2011 ) can be rigorously tested by characterizing the spatial distribution and organization of proximal and distal ce ...

249 There has been a renewed interest in organoid culture in the context of PSC biol- ogy (Clevers 2016 ; Sasai 2013b). As direc ...

250 It can be concluded from these studies that the use of organoids in lung stem cell biology has been a valuable tool for the ...

251 replacement therapies for respiratory diseases. Emerging research areas that are likely to contribute toward this goal are s ...

252 simplest functional units that can model the respective in vivo compartments are a single trachea or airway, a tube-like str ...

253 Chen F, Desai TJ, Qian J, Niederreither K, Lu JN, Cardoso WV (2007) Inhibition of Tgf beta sig- naling by endogenous retinoi ...