Genetics of Apoptosis
caspase-independent necrosis-like PCD seems, at least in some cases, to be the dominant mode of death (Holler et al., 2000). Thi ...
stimulate Fas-induced death by two independent mechanisms, the caspase- independent pathway being evident only when caspase acti ...
a further safeguard mechanism, caspase-inhibitory factors (IAPs and XIAP) have to be removed by additional proteins (DIABLO/SMAC ...
Intracellular control of this pathway is indicated by its susceptibility to attenuation by antioxidants (Vercammen et al., 1998a ...
Finally, endonuclease G or a serine protease, Omi/htra2, released from mitochondria during PCD can contribute to the caspase-ind ...
of PCD, as it is blocked by the antiapoptotic oncogenes Bcl-2 or Bcr-Abl (Amarante- Mendes et al., 1998; Daugas et al., 2000; Si ...
has shown that the same phagocytosis-recognition molecules are involved in removing corpses produced by caspase-dependent apopto ...
virus large T antigen, but not by overexpression of Bcl-2 or inactivation of p53 (Elliott et al., 2000). Similarly, the promyelo ...
inoperable tumors, such as glioblastoma, locoregional gene therapy may prove beneficial. Even though the signaling pathways regu ...
organelles are digested within a stressed cell, and the chance for rescue and reversibility is maintained until the process is c ...
8. Evolution of cell-death principles The driving evolutionary pressures for the development of multiple cell-death Figure 7. De ...
programs have increased in parallel with the increased complexity and life span of organisms (Aravind et al., 2001). But when in ...
9. Conclusion The discovery and understanding of alternative death pathways will open new perspectives for the treatment of dise ...
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Alimonti, J.B., Shi, L., Baijal, P.K. and Greenberg, A.H. (2001) Granzyme B induces BID- mediated cytochrome c release and mitoc ...
Arch, R.H., Gedrich, R.W. and Thompson, C.B. (2000) Translocation of TRAF proteins regulates apoptotic threshold of cells. Bioch ...
BasaƱez, G., Nechushtan, A., Drozhinin, O., et al. (1999) Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bil ...
Berndt, C., Mopps, B., Angermuller, S., Gierschik, P. and Krammer, P.H. (1998) CXCR4 and CD4 mediate a rapid CD95-independent ce ...
Brachmann, C.B., Jassim, O.W., Wachsmuth, B.D. and Cagan, R.L. (2000) The Drosophila bcl-2 family member dBorg-1 functions in th ...
Burtis, K.C., Thummel, C.S., Jones, C.W., Karim, F.D. and Hogness, D.S. (1990) The Drosophila 74EF early puff contains E74, a co ...
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