Genetics of Apoptosis

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Genetics of Apoptosis ...

Genetics of Apoptosis Edited by Stefan Grimm Max-Planck Institute for Biochemistry, Martinsried, Germany ...

© BIOS Scientific Publishers Limited, 2003 All rights reserved. No part of this book may be reproduced or transmitted, in any fo ...

Contents Abbreviations ix Contributors xii Preface xiv Introduction xvi Section I Molecular Biology of Apoptosis Chapter 1 Death ...

7 Caspase targets 44 8 Function of individual caspases 45 Chapter 3 Making sense of the Bcl-2 family of apoptosis regulators Lor ...

3 Apoptosis pathways 123 4 The Bcl-2 protein family 125 5 Structure and channel-forming activity 127 6 Activation of the multido ...

3 Cell death in single-celled eukaryotes 156 4 Conclusions 160 Chapter 9 Programmed cell death in C.elegans Anton GartnerArno Al ...

4 Caspases are required for Rpr-, Grim-, Hid-, and Skl- induced apoptosis 189 5 Modifiers of caspase activation: the mitochondri ...

Abbreviations AD Alzheimer’s disease AICD activation-induced cell death AIF apoptosis-inducing factor ALPS autoimmune lymphoprol ...

DIF differentiation-inducing factor DISC death-inducing signaling complex DKO double knockout DPI diphenyleneiodonium chloride D ...

PDTC pyrrolidine dithiocarbamate PKC protein kinase C PTP permeability transition pore PYD pyrin domains ROS reactive oxygen spe ...

Contributors Alpi, Arno Max-Planck-Institute for Biochemistry, Am Klopferspitz 18a, 82152 Martinsried, Germany Antonsson, Bruno ...

Madeo, Frank Physiologisch-chemisches Institut, Universität Tübingen, Hoppe- Seyler-Straβe 4, D-72076 Tübingen, Germany Ravi, Ra ...

Preface Who would have thought so? Scientists publish paper after paper, gather in meetings, file patents, found companies, esta ...

Dedicated to my parents ...

Introduction Stefan Grimm Given the gravity of the decision between life and death, it is surprising that scientists have only r ...

dramatically, display membrane blebbing and DNA condensation, and are subsequently digested by neighboring cells. Apoptosis, in ...

in progress. We can remain curious as to what Nature still has in store for us to learn about apoptosis. xviii ...

1. Death receptors in apoptosis Rajani Ravi and Atul Bedi 1. Introduction The requirement of cell death to preserve life is no p ...