Cannabinoids

628 M. Guzmán differently in tumour and non-tumour cells. Regarding immune cells, cannabi- noids affect proliferation and surviv ...

Effects on Cell Viability 629 Table 1.Control by cannabinoids of intracellular signalling pathways that may affect cell prolifer ...

630 M. Guzmán from glioma cell lines (Galve-Roperh et al. 2000; Sánchez et al. 2001a; Massi et al. 2004), and in the case of JWH ...

Effects on Cell Viability 631 specific downstream targets of these pathways involved in cannabinoid-induced apoptosis of tumour ...

632 M. Guzmán de novo abrogates the antitumoural effect of cannabinoids in vivo as well as the cannabinoid-induced inhibition of ...

Effects on Cell Viability 633 Experiments conducted on cultured neurons have also provided evidence for a cytoprotective action ...

634 M. Guzmán 3.2 Neurotoxic Effect In contrast to the aforementioned cannabinoid neuroprotection, some studies have reported a ...

Effects on Cell Viability 635 3.3.1 Mechanism of Action —It has been shown that cannabinoids activate two pivotal survival pathw ...

636 M. Guzmán cannabinoids induce apoptosis of leukaemic and lymphoid cells in vitro and—as mentioned above—in mouse models (McK ...

Effects on Cell Viability 637 5 Potential Therapeutic Implications Many studies have dealt with the antiproliferative effect of ...

638 M. Guzmán dual effects on neural cell viability depending on signal input (e.g. agonist dose and time of exposure), high inp ...

Effects on Cell Viability 639 Chan GC, Hinds TR, Impey S, Storm DR (1998) Hippocampal neurotoxicity of∆9-tetra- hydrocannabinol. ...

640 M. Guzmán Guzmán M (2003) Cannabinoids: potential anticancer agents. Nat Rev Cancer 3:745–755 Guzmán M, Galve-Roperh I, Sánc ...

Effects on Cell Viability 641 the anti-proliferative effects of anandamide in human breast cancer cells. FEBS Lett 463:235–240 M ...

642 M. Guzmán Sánchez C, Rueda D, Ségui B, Galve-Roperh I, Levade T, Guzmán M (2001b) The CB1 cannabinoid receptor of astrocytes ...

HEP (2005) 168:643–656 ©cSpringer-Verlag 2005 Effects on Development J.A. Ramos (
)·M.Gómez·R.deMiguel Departamento de Bioquímic ...

644 J.A. Ramos et al. 1 Introduction Marijuana is the most commonly used illicit drug among women of reproductive age. Its use d ...

Effects on Development 645 cognitive development, and behavior showed that the consequences of prenatal exposure to marijuana ar ...

646 J.A. Ramos et al. several effects such as induction of key genes, activation of energy metabolism, arachidonic acid mobiliza ...

Effects on Development 647 2.2 Cannabinoid Ligands Both endocannabinoids, AEA and 2-AG, are present in the whole brains of rat f ...