Cannabinoids

688 M.A. Huestis Manno JE, Manno BR, Kemp PM, Alford DD, Abukhalaf IK, McWilliams ME, Hagaman FN, FitzgeraldMJ(2001)Temporalindi ...

Pharmacokinetics and Metabolism of the Plant Cannabinoids 689 Ohlsson A, Lindgren JE, Wahlen A, Agurell S, Hollister LE, Gillesp ...

690 M.A. Huestis Soares JR, Gross SJ (1976) Separate radioimmune measurements of body fluid delta-9THC and 11-nor-9-carboxy-delt ...

HEP (2005) 168:691–717 ©cSpringer-Verlag 2005 Cannabinoid Tolerance and Dependence A.H. Lichtman (
)·B.R.Martin Department of Ph ...

692 A.H. Lichtman and B.R. Martin we discuss several potential pharmacotherapies that have been examined to treat marijuana depe ...

Cannabinoid Tolerance and Dependence 693 intracranial self-stimulation paradigms. As this issue is the topic of several recent r ...

694 A.H. Lichtman and B.R. Martin tolerance upon subchronic dosing of THC and potent synthetic cannabinoid ago- nists, such as W ...

Cannabinoid Tolerance and Dependence 695 estingly, these changes appear to vary between brain regions, which is likely to accoun ...

696 A.H. Lichtman and B.R. Martin 3.3 CB 1 Receptor-Activated G Proteins and Effectors Agonist-stimulated [^35 S]GTPγS binding h ...

Cannabinoid Tolerance and Dependence 697 cannabinoid administration elevates cAMP that consequently increases PKA ac- tivity (Ru ...

698 A.H. Lichtman and B.R. Martin while increases of only anandamide were found in limbic forebrain of THC-tolerant rats(DiMarzo ...

Cannabinoid Tolerance and Dependence 699 ies indicate a pattern of cannabis withdrawal signs. In an early inpatient study, Jones ...

700 A.H. Lichtman and B.R. Martin was quite prolonged (i.e., 4–14 days). The protracted nature of marijuana with- drawal may con ...

Cannabinoid Tolerance and Dependence 701 ditional behavioral effects including hyperirritability, tremors, and anorexia have bee ...

702 A.H. Lichtman and B.R. Martin SR 141716 was found to precipitate a constellation of withdrawal signs in THC- tolerant dogs t ...

Cannabinoid Tolerance and Dependence 703 cannabinoid-dependent animals (Aceto et al. 1995, 1996; Aceto et al. 1998; Cook et al. ...

704 A.H. Lichtman and B.R. Martin behavioral withdrawal signs are also assessed in an attempt to elucidate the rela- tionship be ...

Cannabinoid Tolerance and Dependence 705 signs of withdrawal including tremors, ataxia, mastication, front paw tremors, pto- sis ...

706 A.H. Lichtman and B.R. Martin et al. 2004). An interpretation of this finding is that increased gene expression in the amygd ...

Cannabinoid Tolerance and Dependence 707 Studies examining acute blockade of opioid receptors in cannabinoid-tolerant animals ha ...