Computational Systems Biology Methods and Protocols.7z
to be more reliable and sensitive at detecting tumor recurrence than CEA. Diehl et al. measured ctDNA in patients after complete ...
EGFR have been shown to be hyperresponsive to the EGFR tyro- sine kinase inhibitor (TKI) gefitinib (IRESSA). The clinical utilit ...
monitored by circulating tumor DNA (ctDNA) using serial plasma samples from NSCLC patients. Monitoring T790M gatekeeper mutation ...
All patients underwent concomitant tissue and blood-based DNA genotyping using the cobas blood test, followed by longitu- dinal ...
On the other hand, the test had a 34% false-negative rate. 36 out of 105 patients tested positive for EGFR mutations in tissue D ...
AURA2, NCT02094261). The positive percentage agreement and negative percentage agreement between tissue and plasma testings were ...
one-third of the patients. Overall, the test identified a molecular alteration in 64% of patients, including 362 NSCLC patients ...
two phase III trials showed that crizotinib was superior to first- and second-line cytotoxic chemotherapy in advanced ALK-rearra ...
PFS of 13.2 months in crizotinib-pretreated patients in one phase I/II trial [75]. On April 28, 2017, brigatinib was accelerated ...
Cohen SJ, Alpaugh RK, Gross S, O’Hara SM, Smirnov DA, Terstappen LW, Allard WJ, Bilbee M, Cheng JD, Hoffman JP, Lewis NL, Pelle ...
Systematic large-scale meta-analysis identifies a panel of two mRNAs as blood biomarkers for colorectal cancer detection. Oncota ...
Oncol Rep 36(2):1166–1172. https://doi. org/10.3892/or.2016.4874 Finney Rutten LJ, Nelson DE (2004) Meissner HI. Examination of ...
Weber B, Meldgaard P, Hager H, Wu L, Wei W, Tsai J, Khalil A, Nexo E, Sorensen BS (2014) Detection of EGFR mutations in plasma ...
harbor EML4-ALK. J Clin Oncol 27 (26):4247–4253. https://doi.org/10.1200/ JCO.2009.22.6993 Inamura K, Takeuchi K, Togashi Y, Ha ...
Chapter 5 Bioinformatics Analysis for Cell-Free Tumor DNA Sequencing Data Shifu Chen, Ming Liu, and Yanqing Zhou Abstract As a m ...
from other tissues. Since both normal and tumor cells shed DNA into the circulation, in general there is a relatively low abunda ...
The adapter ligation efficiency and the number of PCR cycles are two critical factors for this procedure. For hybridization capt ...
heterogeneous mixtures can result in skewed populations, and polymerase errors can result in wrong base incorporations and rearr ...
genome regions with homologous sequences and repetitive sequences. Cell-free DNA fragments are usually short and have a compact ...
be interpreted and reported. These tools can be arranged into a pipeline. Figure3 demonstrates a ctDNA sequencing data analysis ...
«
1
2
3
4
5
6
7
8
9
10
»
Free download pdf