Computational Systems Biology Methods and Protocols.7z
Fox EJ, Reid-Bayliss KS, Emond MJ, Loeb LA (2014) Accuracy of next generation sequenc- ing platforms. Next Gener Seq Appl 1.htt ...
Cox MP, Peterson DA, Biggs PJ (2010) Solex- aQA: at-a-glance quality assessment of Illumina second-generation sequencing data. ...
tumor tissue-of-origin mapping from plasma DNA. Nat Genet 49(4):635–642. https:// doi.org/10.1038/ng.3805 Lin X, Sun D, Rodrigu ...
Chapter 6 An Overview of Genome-Wide Association Studies Michelle Chang, Lin He, and Lei Cai Abstract Genome-wide association st ...
multiple susceptibility alleles, each with small effect sizes (typically increasing disease risk between 1.2 and 2 times the pop ...
1.2 Study Designs and Strategies for GWAS There are two major types of GWAS: population-based studies and family-based studies. ...
This chapter provides an overview of statistical methods for genome-wide association studies. Here we describe how to perform ba ...
Genotyped cases and controls data from the Wellcome Trust Case Control Consortium (WTCCC): https://www.wtccc.org.uk/. Genotyped ...
If no such panel is available for the population from which cases were derived, check if there are other epidemiological studies ...
genotyped. The genotyping results from the duplicate samples are compared, and mismatches between the iden- tical samples are ba ...
associations” [11]. The replication samples should ideally be larger to be well powered to identify spuriously associated SNPs ( ...
(b) Potential issues for performing a meta-analysis across studies: one is that different genotyping platforms may be used, and ...
remaining samples while a combined analysis of data from both stages is conducted [1]. Significant signals, as termed SNPs in GW ...
HapMap to estimate the effective numbernof independent SNPs [20]. Well-designed replication studies are crucial to validate or ...
and haplotype maps. Bioinformatics 21 (2):263–265.https://doi.org/10.1093/bioin formatics/bth457 Spain SL, Barrett JC (2015) St ...
Chapter 7 Integrative Analysis of Omics Big Data Xiang-Tian Yu and Tao Zeng Abstract The diversity and huge omics data take biol ...
developed to investigate the previously thought “dark matter” on genome (e.g., the potential regulatory elements located at nonc ...
into the underlying biological mechanisms [23]. By contrast, in the “top-down integration,” the general integration idea is base ...
levels when and where a gene is active. Beyond such coding infor- mation of biological sequences, the high-order structure of th ...
Recently, the conventional noncoding information or “dark matter” on genome has also been attractive and inspiring to recover ma ...
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