Science - USA (2022-06-10)
versus in G at 72 hours (fig. S9 and table S2). Transcript levels for genes in other clusters were also elevated in the G+M cond ...
proteins. Transcripts related to Fe-S cluster– containing proteins of the electron transport chain complexes I to III, as well a ...
AGING Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice Victoria Acosta-Rodríguez^ ...
was 1 h after the food onset [Zeitgeiber time (ZT) 1 h for CR-day-2h and ZT 13 h for the CR-night-2h]. For the CR-spread group, ...
maintained most activity during the nighttime (Fig. 1, C and D). Therefore, feeding and loco- motor activity are misaligned with ...
versus CR-night animals. However, it has re- cently been shown that sleep homeostasis is maintained in mice under a restricted f ...
(Hmgcr), which is implicated in liver disease and hepatocellular carcinoma ( 38 – 41 )(Fig.3D). Other metabolic genes of note we ...
Acosta-Rodríguezet al., Science 376 , 1192–1202 (2022) 10 June 2022 6of11 A C Aging_DE Up Down Same AL 14% 4% CR.spread 7% 3% CR ...
encoding for microtubule-associated protein tau (Mapt) and apolipoprotein A-IV (Apoa4), the expression of which was up-regulated ...
identified as cycling in the CR-day-2h group. Therefore, we do not recommend putting too much weight on the number of cycling ge ...
maintained with daytime feeding ( 29 ). All CR groups maintained a relatively steady body weight throughout their life span, ind ...
were under a time-restricted feeding proto- col (UW), which should be beneficial. Thus, it would be of considerable interest to ...
C.Liu,S.Li,T.Liu,J.Borjigin,J.D.Lin,Nature 447 ,477–481 (2007). Y. Harada, M. Sakai, N. Kurabayashi, T. Hirota, Y. Fukada, J. B ...
MARINE VIROME Diversity and ecological footprint of Global Ocean RNA viruses Guillermo Dominguez-Huerta1,2,3†, Ahmed A. Zayed1,2 ...
Dominguez-Huertaet al., Science 376 , 1202–1208 (2022) 10 June 2022 2of7 A BC Fig. 1. The cross-domain Global Ocean plankton sam ...
that were inferred for prokaryotic dsDNA viruses (materials and methods; the fifth Bathypelagic zone that was inferred from dsDN ...
Dominguez-Huertaet al., Science 376 , 1202–1208 (2022) 10 June 2022 4of7 Fig. 4. RNA virus“species”-level diversity across depth ...
depth ( 30 ), as does dsDNA virus diversity ( 21 ), and we found that RNA virus diversity also decreases with depth (Fig. 4A and ...
hosts section below), we compared the average number of connectionsper taxon (i.e., mean degree) in polar and nonpolar samples. ...
of a member of specific taxon and an ecosystem output) from classical studies. Notably, previousTarastudies have revealed prokar ...
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