BIOINORGANIC CHEMISTRY A Short Course Second Edition

200 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS html. Na + /K + - ATPase belongs to the P 2 subtype of the P - type ATPase super ...

POTASSIUM-DEPENDENT MOLECULES 201 details in the discussion of Ca 2+ - ATPase, Section 6.4.2.) An informative ribbon display of ...

202 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS using Na + /K + - ATPase from rat (PDB: 1MO7, without ATP, 1MO8, with ATP).^14 ( ...

POTASSIUM-DEPENDENT MOLECULES 203 affected by Na + - or K + - dependent conformational changes. A fl uorescent analog of ATP, TN ...

204 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS visualize ions fl owing through channels that can be opened and closed by dif- f ...

POTASSIUM-DEPENDENT MOLECULES 205 cell. The charged ions create an electrical voltage across the cell membrane. This buildup in ...

206 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS TABLE 5.3 X - Ray Crystallographic Structures of K + Channels Species K + Channe ...

POTASSIUM-DEPENDENT MOLECULES 207 Species K + Channel Type Number of aa Residues/ Molecular Mass (kDa) PDB Accession Number, Res ...

208 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB - P ...

POTASSIUM-DEPENDENT MOLECULES 209 Shaker potassium channel), vertebrate inward rectifi er K + channels (K ir ), Ca 2+ - activate ...

210 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS Figure 5.5 (A) Top - down view of the K + ion channel, PDB: 1BL8. (B) Side view ...

POTASSIUM-DEPENDENT MOLECULES 211 selectivity exhibited by these proteins [faithful discrimination between K + (radius 1.33 Å ) ...

212 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS Conclusions from the 1998 PDB: 1BL8 structural study are as follows: (1) The K + ...

POTASSIUM-DEPENDENT MOLECULES 213 N - terminal end. The researchers also found that inactivation peptides are effective when att ...

214 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS Inactivation peptide interaction with the assembly was used to fi nd answers to ...

POTASSIUM-DEPENDENT MOLECULES 215 It is known that all voltage - dependent ion channels contain six hydrophobic segments per sub ...

216 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS the voltage sensor could pull on the outer helix, thereby affecting the inner S6 ...

POTASSIUM-DEPENDENT MOLECULES 217 Figure 5.7 View of the K + ion channel, the pore helix, and helices S1 – S6, PDB: 1ORQ. Visual ...

218 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS conserved in many K + channels as is shown in reference 18 for 15 different chan ...

POTASSIUM-DEPENDENT MOLECULES 219 Figure 5.8 Closed and opened views of the potassium ion channel pore according to reference 25 ...