BIOINORGANIC CHEMISTRY A Short Course Second Edition

220 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS voltage - sensor paddles remain inaccessible as long as the channel is held clos ...

POTASSIUM-DEPENDENT MOLECULES 221 and changes the kinetics of current activation. The authors believe that incom- plete biotinyl ...

222 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS The preceding conclusions were presented as a new theory about channel pore open ...

POTASSIUM-DEPENDENT MOLECULES 223 family sequences indicated that while trp - tolerant sites varied among the species, trp - int ...

224 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS to each other. Actually, these experiments and others place the N - terminal end ...

POTASSIUM-DEPENDENT MOLECULES 225 closer to the pore than S1 or S3; (4) intersubunit disulfi de bonds — formed after residues in ...

226 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS and S3, N - terminal ends of S2 and S4, and S1 – S2 and S3 – S4 loops are access ...

POTASSIUM-DEPENDENT MOLECULES 227 should be accessible from the membrane ’ s exterior, while glu28, asp72 and glu93 should be ac ...

228 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS propose that S4 docks in the groove between the tetramer subunits with a tilt of ...

POTASSIUM-DEPENDENT MOLECULES 229 channels. The K + channel ’ s pore domain, with the “ inverted tepee ” arrange- ment of inner ...

230 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS ∼ 30 Å in length across the membrane. The T1 domain and β subunit are each ∼ 40 ...

POTASSIUM-DEPENDENT MOLECULES 231 Kv1.2) for their job of attracting cations. Inactivation peptides (also called an inactivation ...

232 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS for the fact that when aShaker K + channel opens, the equivalent of 12 – 14 posi ...

POTASSIUM-DEPENDENT MOLECULES 233 sensor paddles in Kv1.2 are in a slightly different position with respect to helices S1 and S2 ...

234 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS discussed previously in reference 25 for the PDB: 1ORS structure. EPR data gathe ...

exposed surface of the voltage sensor, while arg300 and arg303 interact with acidic residues on helices S1 and S2 inside the vol ...

236 GROUP I AND II METALS IN BIOLOGICAL SYSTEMS (a) Takeda , E. ; Taketani , Y. ; Sawada , N. ; Sato , T. ; Yamamoto , H. Biofa ...

Tiwari - Woodruff , S. K. ; Schulteis , C. T. ; Mock , A. F. ; Papazian , D. M. Biophys J ., 1997 , 72 , 1489 – 1500. Cha , A. ...

238 6 Bioinorganic Chemistry: A Short Course, Second Edition, by Rosette M. Roat-Malone Copyright © 2007 John Wiley & Sons, ...

MAGNESIUM AND CATALYTIC RNA 239 connected the fl anking exon sequences. In Section 2.3.5 , introns were defi ned as sections of ...