Organic Chemistry

Section 24.9 Enzyme-Catalyzed Reactions 1021 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CHC NH + H 2 O CHC O + H 3 N H Gly 193 Ser 195 A ...

PROBLEM 17 Arginine and lysine side chains fit into trypsin’s binding pocket. One of these side chains forms a direct hydrogen ...

Section 24.9 Enzyme-Catalyzed Reactions 1023 CH 2 CH 2 OH Trp 62 Trp 63 C 107 H H H O O O H O RO O O O H H 2 N NH H 2 N C H N CH ...

1024 CHAPTER 24 Catalysis RO NH H NAM CH 2 OH CH 3 CO−O O− O O O CO CO HO NH NAG CH 2 OH CH 3 C CH 2 Asp 52 O O CO O CH 2 Asp 52 ...

Section 24.9 Enzyme-Catalyzed Reactions 1025 345 pH Enzyme activity 678 pK pKa^ = 6.7 a^ = 3.8 >Figure 24.10 Dependence of ly ...

1026 CHAPTER 24 Catalysis Overall Reaction HO^ H HO^ H H OH H OH H B+ − (^2) O 3 POCH 2 − (^2) O 3 POCH 2 D-glucose-6-phosphate ...

Section 24.9 Enzyme-Catalyzed Reactions 1027 PROBLEM 21 When D-glucose undergoes isomerization in the absence of the enzyme, thr ...

1028 CHAPTER 24 Catalysis CH 2 OPO 32 – CH 2 OPO 32 – CH 2 OPO 32 – H 2 N(CH 2 ) 4 Lys CH 2 OPO 32 – CH 2 OPO 32 – C HO H OH OH ...

Key Terms 1029 Key Terms acid catalyst (p. 000) active site (p. 1015) acyl-enzyme intermediate (p. 1020) base catalyst (p. 1006) ...

1030 CHAPTER 24 Catalysis Problems Which of the following two compounds would eliminate HBr more rapidly in basic solutions? Wh ...

Problems 1031 There are two kinds of aldolases. Class I aldolases are found in animals and plants; Class II aldolases are found ...

1032 CHAPTER 24 Catalysis Proof that an imine was formed between aldolase and its substrate was obtained by using D-fructose-1, ...

25 The Organic Mechanisms of the Coenzymes • Metabolism 1033 N^5 ,N^10 -methylenetetrahydrofolate Casimir Funk (1884–1967)was bo ...

1034 CHAPTER 25 The Organic Mechanisms of the Coenzymes • Metabolism coenzymes play a variety of chemical roles that the amino a ...

Section 25.1 Overall View of Metabolism 1035 Sir Frederick G. Hopkins (1861–1947)was born in England. His finding that one sampl ...

1036 CHAPTER 25 The Organic Mechanisms of the Coenzymes • Metabolism CO 2 CO 2 NADH Stage 1 fats fatty acids Stage 3 Stage 4 Sta ...

Section 25.1 Overall View of Metabolism 1037 Figure 25.2 Glycolysis—the series of enzyme-catalyzed reactions responsible for th ...

1038 CHAPTER 25 The Organic Mechanisms of the Coenzymes • Metabolism Figure 25.3 The citric acid cycle (also known as the Krebs ...

Section 25.2 Niacin: The Vitamin Needed for Many Redox Reactions 1039 NADand NADPare oxidizing agents. 25.2 Niacin: The Vitami ...

1040 CHAPTER 25 The Organic Mechanisms of the Coenzymes • Metabolism The heterocyclic component of one of the nucleotides of is ...