Exercise for Cardiovascular Disease Prevention and Treatment From Molecular to Clinical, Part 1

305 Scott D, Tan Y, Shandas R et  al (2013) High pulsatility flow stimulates smooth muscle cell hypertrophy and contractile pro ...

306 Mizuno M, Iwamoto GA, Vongpatanasin W et al (2014) Exercise training improves func- tional sympatholysis in spontaneously h ...

© Springer Nature Singapore Pte Ltd. 2017 307 J. Xiao (ed.), Exercise for Cardiovascular Disease Prevention and Treatment, Advan ...

308 1 Introduction Pulmonary arterial hypertension (PAH) is a disorder of the pulmonary circulation and it is defined by hemodyn ...

309 they should undertake supervised ExT under medical therapy [ 1 ]. Despite this major change regarding the role of exercise i ...

310 3 Exercise Training and the Right Heart in Pulmonary Arterial Hypertension The primary cause of death in patients with PAH i ...

311 Table 17.1 Characterization of training programs used to evaluate the impact of exercise training in pre-clinical models of ...

312 Table 17.2 Characterization of pre-clinical models of Pulmonary Arterial Hypertension and summary of the main changes induce ...

313 was able to delay the onset of RV failure [ 28 ]. The impact of ExT on the cardiovas- cular system is also dependent on the ...

314 in PAH should enroll patients in different stages of the disease, so that we could have solid evidence over the entire spect ...

315 shape, the leftward septal bowing and the enlargement of the right atrium [ 27 ], all of which are classical features of mal ...

316 [ 27 ], which may have contributed to improve cardiac capillary density in MCT- induced PAH [ 32 , 33 ]. Oxidative stress ha ...

317 selves, and particularly oxidative phosphorylation complexes, are highly susceptible to oxidative and nitrative damage [ 75 ...

318 and possibly cellular trans-differentiation (i.e., endothelial- mesenchymal transfor- mation) [ 83 ]. In addition, severe fo ...

319 to respiratory functional parameters, higher PaO 2 and lung diffusing capacity at rest and during maximal exercise were desc ...

320 References Galie N, Humbert M, Vachiery JL et  al (2016) 2015 ESC/ERS guidelines for the diagnosis and treatment of pulmona ...

321 Vonk-Noordegraaf A, Haddad F, Chin KM et al (2013) Right heart adaptation to pulmonary arterial hypertension: physiology an ...

322 van de Veerdonk MC, Kind T, Marcus JT et al (2011) Progressive right ventricular dysfunction in patients with pulmonary art ...

323 Piao L, Marsboom G, Archer SL (2010) Mitochondrial metabolic adaptation in right ventricu- lar hypertrophy and failure. J M ...

324 Favret F, Henderson KK, Clancy RL et al (2001) Exercise training alters the effect of chronic hypoxia on myocardial adrener ...