Cannabinoids
Molecular Biology of Cannabinoid Receptors 93 that the TM3 of the cannabinoid receptor imparts selectivity of aminoalkylindoles ...
94 M.E. Abood a receptor with WT properties. Overall, these results suggest the e2 domain and corresponding cysteines are import ...
Molecular Biology of Cannabinoid Receptors 95 receptors. Substitutions to aromatic residues phenylalanine or tyrosine as well as ...
96 M.E. Abood sequent studies extended these findings to CB 1 receptor-activated guanosine-5′- O-(3-thiotriphosphate) (GTPγS) bi ...
Molecular Biology of Cannabinoid Receptors 97 levels of constitutive activity compared to WT CB 1. This result supports the hy- ...
98 M.E. Abood in neurons (Nie and Lewis 2001b). The consequences of mutation of D2.50, a highly conserved residue present in mos ...
Molecular Biology of Cannabinoid Receptors 99 proposed to be due to a conformational change in the CB 2 receptor, rather than a ...
100 M.E. Abood the mutant mice lose responsiveness to cannabinoids, the reinforcing properties of morphine and the severity of t ...
Molecular Biology of Cannabinoid Receptors 101 They identified a silent mutation in T453 (G to A)—a conserved amino acid present ...
102 M.E. Abood receptor-G protein coupling was subsequently confirmed (Breivogel et al. 1999). Brain region specificity of recep ...
Molecular Biology of Cannabinoid Receptors 103 produced the most tolerance in vivo (Fan et al. 1994). In most in vitro studies, ...
104 M.E. Abood The first report of alteration of CB 2 receptor expression was in the original cloning paper; CB 2 was isolated a ...
Molecular Biology of Cannabinoid Receptors 105 A cannabinoid receptor subtype has been found in the hippocampus that is responsi ...
106 M.E. Abood agonists, that there is a complex molecular architecture of the cannabinoid recep- tors. This arrangement allows ...
Molecular Biology of Cannabinoid Receptors 107 Bouaboula M, Desnoyer N, Carayon P, Combes T, Casellas P (1999a) Gi protein modu- ...
108 M.E. Abood Di Marzo V, Fontana A, Cadas H, Schinelli S, Cimino G, Schwartz J-C, Piomelli D (1994) Formationandinactivationof ...
Molecular Biology of Cannabinoid Receptors 109 Gardner E, Lowinson J (1991) Marijuana’s Interaction with Brain Reward Systems: U ...
110 M.E. Abood Hsieh C, Brown S, Derleth C, Mackie K (1999) Internalization and recycling of the CB1 cannabinoid receptor. J Neu ...
Molecular Biology of Cannabinoid Receptors 111 KumarV,AlexanderMD,BellMR,EissenstatMA,CasianoFM,ChippariSM,HaycockDA, LutingerDA ...
112 M.E. Abood Mechoulam R, Hanus L, Ben-Shabat S, Fride E, Weidenfeld J (1994) The anandamides, a family of endogenous cannabin ...
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