Cannabinoids
134 O. Valverde et al. (Cohen et al. 2002). Another study also supports the hypothesis that endocannabi- noids acting on CB 1 re ...
Analysis of the Endocannabinoid System by Using CB 1 Cannabinoid Receptor Knockout Mice 135 et al. 1998; Williams and Kirkham 20 ...
136 O. Valverde et al. 1999). Endocannabinoids are probably synthesized by Ca2+-dependent postsy- naptically localized enzymes ( ...
Analysis of the Endocannabinoid System by Using CB 1 Cannabinoid Receptor Knockout Mice 137 imals reflects the diversity of func ...
138 O. Valverde et al. Bhargava HN, Way EL (1976) Morphine tolerance and physical dependence: influence of cholinergic agonists ...
Analysis of the Endocannabinoid System by Using CB 1 Cannabinoid Receptor Knockout Mice 139 DeVriesTJ,ShahamY,HombergJR,CrombagH ...
140 O. Valverde et al. Ghozland S, Matthes HW, Simonin F, Filliol D, Kieffer BL, Maldonado R (2002) Motiva- tional effects of ca ...
Analysis of the Endocannabinoid System by Using CB 1 Cannabinoid Receptor Knockout Mice 141 Jarai Z, Wagner JA, Varga K, Lake KD ...
142 O. Valverde et al. Lichtman AH, Sheikh SM, Loh HH, Martin BR (2001) Opioid and cannabinoid modulation of precipitated withdr ...
Analysis of the Endocannabinoid System by Using CB 1 Cannabinoid Receptor Knockout Mice 143 MazzariS,CanellaR,PetrelliL,Marcolon ...
144 O. Valverde et al. Rodriguez de Fonseca F, Gorriti MA, Fernandez-Ruiz JJ, Palomo T, Ramos JA (1994) Down- regulation of rat ...
Analysis of the Endocannabinoid System by Using CB 1 Cannabinoid Receptor Knockout Mice 145 TzavaraET,DavisRJ,PerryKW,LiX,Salhof ...
HEP (2005) 168:147–185 ©cSpringer-Verlag 2005 The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids V. D i M ...
148 V. Marzo et al. endocannabinoids. This in turn meant that the enzymes catalysing endocannabi- noid biosynthesis and inactiva ...
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids 149 Fig. 1.Established and newly proposed endocannabin ...
150 V. Marzo et al. pathways underlying the production of the two major endocannabinoids will be discussed here separately. In g ...
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids 151 Fig. 2. Major biosynthetic pathways and enzymes fo ...
152 V. Marzo et al. However, a recent study (Sun et al. 2004) also highlights another possible way for NAPEs to be transformed i ...
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids 153 Stella et al. 1997). Twosn-1 DAG lipase isozymes ( ...
154 V. Marzo et al. of 2-alkenyl glyceryl ethers from the corresponding fatty acyl alcohols; and (3) although similar enzymes ha ...
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