Cannabinoids
72 A.C. Howlett FimianiC,MattocksD,CavaniF,SalzetM,DeutschDG,PryorS,BilfingerTV,StefanoGB (1999b) Morphine and anandamide stimul ...
Cannabinoid Receptor Signaling 73 Herkenham M, Lynn AB, Little MD, Johnson MR, Melvin LS, De Costa BR, Rice KC (1990) Cannabinoi ...
74 A.C. Howlett Jin W, Brown S, Roche JP, Hsieh C, Celver JP, Kovoor A, Chavkin C, Mackie K (1999) Distinct domains of the CB1 c ...
Cannabinoid Receptor Signaling 75 Melvin LS, Milne GM, Johnson MR, Subramaniam B, Wilken GH, Howlett AC (1993) Structure-activit ...
76 A.C. Howlett Pacheco M, Childers SR, Arnold R, Casiano F, Ward SJ (1991) Aminoalkylindoles: actions on specific G-protein-lin ...
Cannabinoid Receptor Signaling 77 Roth SH, Williams PJ (1979) The non-specific membrane binding properties of delta9-tetra- hydr ...
78 A.C. Howlett Stefano GB, Liu Y, Goligorsky MS (1996) Cannabinoid receptors are coupled to nitric oxide release in invertebrat ...
Cannabinoid Receptor Signaling 79 Varma N, Carlson GC, Ledent C, Alger BE (2001) Metabotropic glutamate receptors drive the endo ...
HEP (2005) 168:81–115 ©cSpringer-Verlag 2005 Molecular Biology of Cannabinoid Receptors M.E. Abood Forbes Norris MDA/ALS Researc ...
82 M.E. Abood residues involved in the selective recognition of these ligands. Numerous residues involved in receptor activation ...
Molecular Biology of Cannabinoid Receptors 83 and cells of the immune system, has 44% amino acid identity with CB 1 ,andadis- ti ...
84 M.E. Abood ent conformations of the CB 1 receptor, which in turn can activate select G proteins (Glass and Northup 1999; Grif ...
Molecular Biology of Cannabinoid Receptors 85 Fig. 1.A helix net representation of the human CB 1 receptor. The amino acids shar ...
86 M.E. Abood Fig. 2.An alignment of the human CB 1 and CB 2 receptors. The transmembrane domains areunderlined.The standard sin ...
Molecular Biology of Cannabinoid Receptors 87 3 Gene Structure and Species Diversity Shortly after the cloning of the rat cannab ...
88 M.E. Abood rat clones have 95% nucleic acid identity (100% amino acid identity). The mouse and human clones have 90% nucleic ...
Molecular Biology of Cannabinoid Receptors 89 4 Ligand Recognition at the CB 1 Receptor 4.1 The Aminoalklylindole/SR141716A Bind ...
90 M.E. Abood several turns of TMHs 3, 4, and 5 that is likely to be energetically favored. Similarly, studies in the Reggio lab ...
Molecular Biology of Cannabinoid Receptors 91 less of a loss than observed with the corresponding insertion mutant. This pattern ...
92 M.E. Abood formed by the TMH bundle, and the hydrophobic cluster of amino acids on helices 6 and 7 form the hydrophobic pocke ...
«
1
2
3
4
5
6
7
8
9
10
»
Free download pdf