Cannabinoids
Pharmacological Actions of Cannabinoids 11 et al. 2003). It has also proved possible to assay cannabinoid receptor agonists by e ...
12 R.G. Pertwee selectivity since, in contrast to established CB 1 receptor agonists, many other classes of centrally active age ...
Pharmacological Actions of Cannabinoids 13 3CB 1 and CB 2 Cannabinoid Receptor Ligands 3.1 CannabinoidReceptorAgonists In terms ...
14 R.G. Pertwee Fig. 5.The structures of four nonclassical cannabinoids – Nonclassical cannabinoids consist of bicyclic and tric ...
Pharmacological Actions of Cannabinoids 15 Fig. 6.The structures of four nonclassical cannabinoids. The (+)-enantiomer of CP5594 ...
16 R.G. Pertwee Fig. 8.The structures of eight structural analogues of anandamide Many cannabinoid receptor agonists exhibit mar ...
Pharmacological Actions of Cannabinoids 17 –(–)-∆^9 -THC has lower CB 1 and CB 2 affinities and relative intrinsic activities th ...
18 R.G. Pertwee Fig. 9.The structures of BAY 38-7271, JTE-907, ajulemic acid and O-1057 activity of virodhamine matched that of ...
Pharmacological Actions of Cannabinoids 19 Table 4.Kivalues of certain other ligands for the in vitro displacement of [^3 H]CP55 ...
20 R.G. Pertwee methyl-2-hydroxyethyl)-2-R-methyl-arachidonamide, which also exhibits marked CB 1 -selectivity in binding assays ...
Pharmacological Actions of Cannabinoids 21 Fig. 10.The structures of several CB 1 -orCB 2 -selective antagonists/inverse agonist ...
22 R.G. Pertwee transient receptor potential vanilloid type 1 (TRPV1) receptors (previously known as VR1 receptors), suggesting ...
Pharmacological Actions of Cannabinoids 23 that are opposite in direction to those produced by the activation of CB 1 receptors ...
24 R.G. Pertwee SR144528 has greater inverse intrinsic activity than AM630. If this interpretation of the data is valid, it is o ...
Pharmacological Actions of Cannabinoids 25 Fig. 11.The structure of O-1184 and of some putative neutral cannabinoid receptor ant ...
26 R.G. Pertwee 4 Other Pharmacological Targets for Cannabinoids in Mammalian Tissues... As discussed in greater detail elsewher ...
Pharmacological Actions of Cannabinoids 27 in healthy tissue, one role of anandamide may be to act through CB 1 receptors to opp ...
28 R.G. Pertwee Sheskin et al. 1997; Showalter et al. 1996), the antinociceptive effects of this fatty acid amide are opposed by ...
Pharmacological Actions of Cannabinoids 29 – It is not sensitive to activation by the established CB 1 /CB 2 receptor agonists,∆ ...
30 R.G. Pertwee obtainedfromratsorCB 1 +/+CD1 mice have shown thatR-(+)-WIN55212 reduces both excitatory postsynaptic currents ( ...
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