Cannabinoids
Pharmacological Actions of Cannabinoids 51 Walker JM, Krey JF, Chu CJ, Huang SM (2002) Endocannabinoids and related fatty acid d ...
HEP (2005) 168:53–79 ©cSpringer-Verlag 2005 Cannabinoid Receptor Signaling A.C. Howlett Neuroscience/Drug Abuse Research Program ...
54 A.C. Howlett receptors leads to phosphorylation and activation of p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK a ...
Cannabinoid Receptor Signaling 55 triphosphate (GTP) concentrations for Gi-mediated inhibition of adenylyl cyclase (Howlett 1985 ...
56 A.C. Howlett 2 The Cyclic AMP and Protein Kinase A Signal Transduction Pathway 2.1 Cannabinoid Receptor-Mediated Inhibition o ...
Cannabinoid Receptor Signaling 57 Inhibition of forskolin-stimulated cyclic AMP production has been pharmaco- logically characte ...
58 A.C. Howlett consistent with Gi mediation of the inhibition component and Gs mediation of the stimulation component. The find ...
Cannabinoid Receptor Signaling 59 couple to IP 3 or phosphatidic acid release (Felder et al. 1992, 1995). Furthermore, cannabino ...
60 A.C. Howlett response. P/Q-type Ca2+fluxes, detected by fura-2 fluorescence in rat cortical and cerebellar preparations, were ...
Cannabinoid Receptor Signaling 61 Misner and Sullivan 1999), other brain areas in which neurotransmission appears to be modulate ...
62 A.C. Howlett One mechanism for p42/p44 MAPK activation by CB 1 receptors coupled to Gi/o could utilize the Gβγdimer to provid ...
Cannabinoid Receptor Signaling 63 cells showed an induction of genes involved in cytokine synthesis, regulation of transcription ...
64 A.C. Howlett whether NOS in neurons was responsible (Prevot et al. 1998). The presence of Ca2+- dependentconstitutiveNOSinN18 ...
Cannabinoid Receptor Signaling 65 it can serve as a regulator of transient receptor potential vanilloid type 1 (TRPV1, formerly ...
66 A.C. Howlett al. 1999; Howlett et al. 1998). In solubilized brain or N18TG2 membrane prepa- rations, the juxtamembrane C-term ...
Cannabinoid Receptor Signaling 67 acid residues in TM3 and TM6 would be predicted, which may release inter-helical bonds and tri ...
68 A.C. Howlett posure to∆^9 -THC and levonantradol in cultured neuroblastoma cells (Dill and Howlett 1988; Shapira et al. 1998) ...
Cannabinoid Receptor Signaling 69 ipate in signal transduction via scaffolding mechanisms, including regulation of MAPK signalin ...
70 A.C. Howlett Bouaboula M, Bourrie B, Rinaldi-Carmona M, Shire D, Le Fur G, Casellas P (1995a) Stimu- lation of cannabinoid re ...
Cannabinoid Receptor Signaling 71 Deadwyler SA, Hampson RE, Mu J, Whyte A, Childers S (1995) Cannabinoids modulate voltage sensi ...
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