Clinical_Rounds_in_Endocrinology_Volume_II_-_Pediatric_Endocrinology

© Springer India 2016 1 A. Bhansali et al., Clinical Rounds in Endocrinology, DOI 10.1007/978-81-322-2815-8_1 1 Disorders of Gro ...

2 HCO 3 −), calcium profile, and IgA tTG were normal. Hormonal profile showed serum T 4 6.7 μg/dl (N 4.8–12.7), TSH 4.6 μIU/ml ( ...

3 Fig. 1.1 A child with GH deficiency. Note (a) cherubic face, frontal bossing and midfacial hypo- plasia (b) short stature, mic ...

4 ef Fig. 1.1 (continued) 1 Disorders of Growth and Development: Clinical Perspectives ...

5 g Fig. 1.1 (continued) 1 Disorders of Growth and Development: Clinical Perspectives ...

6 1.2 Stepwise Analysis The index child was born of full-term normal vaginal delivery with birth weight of 3.3 Kg, thereby mitig ...

7 excludes the diagnosis of intrinsic short stature. The index patient had typical facies of growth hormone (GH) deficiency as h ...

8 evolution of de novo TSH deficiency. Weight-based dosage is recommended for the initiation of rhGH therapy and monitoring is p ...

9 Age Height velocity (per year) Birth – 0–1 year 25 cm 1–2 year 12.5 cm 2–3 year 8 cm 3 years – puberty 5 cm Puberty Boys 9.5 c ...

10 promoting uteroplacental blood flow. In addition, it also regulates the growth and differentiation of chondrocytes during fet ...

11 Epiphysis Metaphysis PHYSIS (GROWTH PLATE): Zone of resting cartilage Zone of proliferating cartilage Zone of hypertrophic ca ...

12 GH IGF- 1 GC T3 Pro-proliferative Pro-proliferative Growth arrest, inhibits hypertrophic differentiation Antiproliferative, p ...

13 How does circumferential bone growth occur in a child? The linear bone growth occurs at epiphyseal growth plate (at the end ...

14 height during pubertal growth spurt (3 cm) in boys. This knowledge is impor- tant and is used in the calculation of midparent ...

15 Why is total IGF1 level normal despite low GH levels in obesity? Obesity is associated with normal IGF1 despite low GH leve ...

16 What is the importance of measuring body proportions in a short child? Measurement of body proportions helps in the differe ...

17 Short stature Dysmorphic features Present Turner’s syndrome Down’s syndrome Noonan’s syndrome Prader-Willi syndrome Russell- ...

18 a boy is 157 cm and mean adult height of the population is 177 cm for males (50th percentile in CDC growth chart), there is a ...

19 parameters of healthy children of different age at a given point of time, while the “longitudinal growth charts” are construc ...

20 for initial 2 years of life. However, WHO growth standards are available for only 0–5 years of age, and later monitoring is r ...