A Textbook of Clinical Pharmacology and Therapeutics

210 ANTICOAGULANTS AND ANTIPLATELETDRUGS FURTHER READING Hirsh J, O’Donnell M, Weitz JI. New anticoagulants. Blood2005; 105 : 45 ...

●Introduction 211 ●Pathophysiology and implications for treatment 211 ●Therapeutic objectives and general measures for chronic h ...

we focus on aspects common to heart failure irrespective of aetiology. Heart failure triggers ‘counter-regulatory’ responses (Fi ...

The drugs that are most effective in prolonging survival in chronic heart failure work indirectly, by reducing preload, afterloa ...

Precautions in terms of first-dose hypotension and monitoring creatinine and electrolytes are similar to those for ACEI. β-ADREN ...

therapeutic plasma concentration can be obtained more rap- idly by administering a loading dose (Chapter 3). Mechanism of action ...

(c)A detailed personal/social history (d)Substitution of allopurinol for the meclofenamate (e)Hold the bendroflumethiazide tempo ...

●Common dysrhythmias 217 ●General principles of management 218 ●Classification of anti-dysrhythmic drugs 218 ●Cardiopulmonary re ...

Intranodal supraventricular tachycardia Fibre tracts in the AV node are arranged longitudinally, and if differences in refractor ...

BASIC LIFE SUPPORT When a person is found to have collapsed, make a quick check to ensure that no live power lines are in the im ...

and check that the chest falls between respirations. If avail- able, 100% oxygen should be used. Check for a pulse by feeling ca ...

arrest. The electrocardiogram is likely to show asystole, severe bradycardia or ventricular fibrillation. Occasionally narrow co ...

provides a simple and practical algorithm for the manage- ment of tachydysrhythmias in general. Catheter ablation therapy is now ...

should be given to insertion of an implantable cardioverter defibrillator (ICD), if the patient is considered at high risk of fu ...

inappropriate sinus tachycardia (e.g. in association with panic attacks); paroxysmal supraventricular tachycardias that are pre ...

Drug interactions Amiodaronepotentiateswarfarinby inhibiting its metab- olism. It can precipitate digoxintoxicity (the digoxindo ...

(as is not infrequently the case) and the patient actually has VT, little or no harm results, in contrast to the use of verapami ...

effect when treating sinus bradycardia, in the event of haemo- dynamic compromise, for example following myocardial infarction. ...

deficiency, since Mg^2 is predominantly an intracellular cation. However, serial plasma magnesium determinations may be useful ...

FURTHER READING Delacretaz E. Clinical practice: supraventricular tachycardia. New England Journal of Medicine2006; 354 : 1039–5 ...