Genetics of Apoptosis
TCR selection mature into CD4+ CD8+ T cells and undergo further positive and negative selection depending on the affinity of the ...
Ligation of the antigen-specific B-cell receptor (BCR) alone is an insufficient signal to activate a B cell and instead results ...
caspase-8), the truncated BID generated by granzyme B (gtBID) translocates to the mitochondrial membrane and promotes the releas ...
apoptosis. Defects of the CD95-CD95L system also result in similar immune disorders in humans (Fisher et al., 1995; Rieux-Laucat ...
overexpression of Bcl-2 or Bcl-xL exhibit extended cell survival and pathologic cellular accumulation in the targeted tissues (S ...
tumors by NK cells. Expression of FasL on cells other than NK cells might also contribute to tumor suppression (Owen-Schaub et a ...
Although death receptors play contributory, yet dispensable, roles in the response to conventional chemotherapy or irradiation, ...
is associated with activation of NF-κB-induced antiapoptotic target genes (Altucci et al., 2001). Since the majority of patients ...
bearing animals without any deleterious effects on normal tissues. Likewise, monoclonal antibodies that engage the human Apo2L/T ...
death receptor signals, including activation of caspase-8 and cleavage of BID, Apo2L/ TRAIL could not induce mitochondrial disru ...
will test whether our investment in defining the basic mechanisms of cell death will harvest rich dividends in diverse fields of ...
2. The role of caspases in apoptosis Sharad Kumar and Dimitrios Cakouros 1. What are caspases? As the name suggests, caspases (c ...
addition to the regions that give rise to two subunits, procaspases contain N— terminal prodomains of varying lengths. By the le ...
contain a pair of death effector domains (DEDs) in their prodomain regions (reviewed in Kumar, 1999; Kumar and Colussi, 1999; Sh ...
example, mammalian caspase-2, and Drosophila DRONC and DAMM prefer a minimum of five residues in the substrates, and tetrapeptid ...
TNFR1, DR3, DR4, and DR5) and the adaptor molecules that are recruited to these receptors (e.g., FADD and TRADD) (reviewed in As ...
5.2 Activation of caspase-8 Mammalian caspase-8 and -10, and the fly caspase DREDD contain two DEDs in their prodomain region (B ...
to enhance allosterically caspase-9 activity, rather than mediate its cleavage. The recombinant procaspase-9, containing mutatio ...
of cytochrome c in caspase activation in C.elegans. The role of cytochrome c in caspase activation in Drosophila is also current ...
6.1 Regulation of caspase-8 activation by FLIPs Many viruses encode apoptosis inhibitors to avoid the host’s apoptotic response. ...
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