Genetics of Apoptosis
viruses encoding these proteins belong to two different classes: most of them are γ- herpesviruses, while the poxvirus MCV (moll ...
and only speculations on the possible interaction surfaces exist (Eberstadt et al., 1998; Weber and Vincenz, 2001a). Functionall ...
triggering of the mitochondrial permeability pore, cytochrome c is released from the mitochondrium and binds to the WD-40 repeat ...
Domain abbreviations: CARD, caspase recruitment domain; DD, death domain; NB- ARC, ATPase domain; NACHT, ATPase domain; BIR, IAP ...
in a number of proteins that also contain a CARD domain, including ASC/Pycard, Nod1/CARD4, and NALP1. The grown recognition for ...
3.5 The Toll/IL-1R domain (TIR) The TIR domain can with some justification be grouped with the death adapter domains, although i ...
protein known to interact with TIR receptors. MyD88 is still considered the major adapter in TIR signaling, as it seems to play ...
molecule inhibitor. According to the structure, an activated caspase consists of two p20/p10 heterodimers. In the structure, the ...
include a yeast protein. Another ancient family of cysteine proteases with relationship to caspases are the insulinase-like enzy ...
5. Other important domains The domains discussed in the previous sections serve to initiate an apoptosis signal and to relay it ...
by several amphipathic helices carrying the BH motifs. Of particular interest is a structure of the antiapoptotic Bcl-xL protein ...
including the regulation of pre-existing membrane pores of the mitochondrium by association with proapoptotic family members (Sh ...
Shortly after the discovery of the NB-ARC ATPases, a related domain family was described, which tends to occur in a similar set ...
architecture are shown in Figure 2. The N-terminus of the proteins is occupied by an adapter-type domain, which can be either CA ...
conformational change, maybe by extracting the CARD domain out of an inhibitory interaction adopted in the nonsignaling state. I ...
5. The role of the endoplasmic reticulum in apoptosis David G.Breckenridge and Gordon C.Shore 1. Introduction When a metazoan ce ...
studies on how stress in the ER is coupled to apoptosis have demonstrated that the ER, like mitochondria, can directly initiate ...
translated, generating Haclp, a basic leucine zipper (bZIP) transcription factor that activates the transcription of ER chaperon ...
2.2 ER stress-induced apoptotic signal transduction pathways Through its three signaling arms, the UPR stalls synthesis of new p ...
finding provides an explanation of how CHOP sensitizes cells to ER stress and why CHOP-/- cells are more resistant to tunicamyci ...
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