Genetics of Apoptosis
biochemical data suggest that RPR, HID, and GRIM promote cell death by disrupting DIAP1-caspase interactions and that DIAP1 is r ...
The BH3-only proteins share sequence homology with Bcl-2 only in the BH3 domain, which is required to interact with other Bcl-2 ...
Hogness, 1990; DiBello et al., 1991). These transcription factors then regulate secondary response genes. Ten hours after pupari ...
fragment that promotes the characteristic rounding-up of cells (Kothakota et al., 1997). PAK2, a serine/threonine kinase, is act ...
tube closure is seen in the hindbrain region at E10.5 of casp9-/- embryos. These mutants also have enlarged proliferation zones ...
1998; O’Reilly et al., 2002). Furthermore, DRG neurons from these mice undergo factor-withdrawal-induced cell death as wild-type ...
controlling cell number during brain and eye development and the morphogenetic cell death in the brain, skull, face, eye, and li ...
3. Making sense of the Bcl-2 family of apoptosis regulators Loralee Haughn and David Hockenbery 1. Introduction Although they we ...
later, expression of Bax was shown to be capable of directly triggering apoptosis (Xiang et al., 1996). Since the discovery of B ...
the original rheostat model, both anti- and proapoptotic BH proteins form homodimers or associate as mixed heterodimers (Korsmey ...
that disrupt heterodimeric interactions without disabling their respective apoptotic functions (Cheng et al., 1996; Simonian et ...
mildly weakened by the potentially redundant expression of other pro- and antiapoptotic family members capable of partnering wit ...
Bax to mitochondria during apoptosis is accompanied by a significant lag period between Bax translocation and cytochrome c relea ...
CsA has mitochondrial effects beyond inhibition of PTP cannot be excluded (Jurgensmeier et al., 1998). Not all reports agree tha ...
2.7 Proapoptotic functions: different designs What conclusions can be drawn from the inconsistent results cited above? Mitochond ...
Table 2 . Experimental conditions for Bax studies with isolated mitochondria Abbrev. BKA bongterekic acid; Cr creatine; PCr phos ...
2.8 Antiapoptotic functions: membrane permeability An intrinsic activity of Bcl-2-type survival proteins has been more difficult ...
the Vander Heiden study might be more significant for passage of uncharged organic molecules. Why do Bcl-2 and Bcl-xL form chann ...
Mutational studies of Bcl-2 and Bcl-xL have directed attention to the hydrophobic cleft bordered by α-helices 2–5 and 7–8 (inclu ...
in Bcl-2). Additionally, these residues form hydrogen bonds at the NH 2 -terminal end of α5, from the loop joining α4 and α5 (Ar ...
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