A Textbook of Clinical Pharmacology and Therapeutics

310 REPRODUCTIVE ENDOCRINOLOGY disease, severe hypertension, migraine with focal neurological symptoms, severe liver disease, po ...

FEMALEREPRODUCTIVEENDOCRINOLOGY 311 Treatment with depot progestogeninjections should not be undertaken without full counselling ...

312 REPRODUCTIVE ENDOCRINOLOGY Oestrogens used in HRT include conjugated oestrogens, mestranol,estradiol,estriolandoestropipate. ...

MALEREPRODUCTIVEENDOCRINOLOGY 313 infusion using an infusion pump to induce or augment labour, usually in conjunction with ruptu ...

314 REPRODUCTIVE ENDOCRINOLOGY symptoms. Alternatively, testosterone undecanoateormes- terolonecan be taken by mouth; these drug ...

MALEREPRODUCTIVEENDOCRINOLOGY 315 significant proportion of men who receive placebo discontinue their participation because of t ...

●Anterior pituitary hormones and related drugs 316 ●Posterior pituitary hormones 318 CHAPTER 42 THE PITUITARY HORMONES AND RELAT ...

ANTERIORPITUITARYHARMONES ANDRELATEDDRUGS 317 with symptoms caused by the release of pharmacologically active substances from ga ...

318 THE PITUITARY HORMONES AND RELATED DRUGS and thereby reduce pituitary stimulation of male or female gonads, effectively lead ...

POSTERIORPITUITARYHARMONES 319 FURTHER READING Birnbaumer M. Vasopressin receptors. Trends in Endocrinology and Metabolism2000; ...

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PART IX SELECTIVE TOXICITY ...

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●Principles of antibacterial chemotherapy 323 ●Bacterial resistance 324 ●Drug combinations 325 ●Prophylactic use of antibacteria ...

site of infection may be considerably lower than the plasma concentration which one might predict to be bactericidal (e.g. drug ...

2.transfer of resistance between organisms can occur by transfer of naked DNA (transformation), by conjugation with direct cell- ...

ofpenicillin. This interaction may be used therapeutically to produce higher and more prolonged blood concentrations of penicill ...

Pharmacokinetics Absorption of these drugs from the gut is inadequate in the life-threatening infections for which they are main ...

Enterococcus faecalis, but not (when used alone) against other streptococci. They synergize with penicillins in killing Streptoc ...

Mechanism of action Macrolides bind to bacterial 50S ribosomes and inhibit protein synthesis. Pharmacokinetics Well absorbed ora ...