A Textbook of Clinical Pharmacology and Therapeutics

370 CANCER CHEMOTHERAPY Sometimes vomiting may be anticipatory and this may be minimized by treatment with benzodiazepines. It i ...

DRUGSUSED INCANCERCHEMOTHERAPY 371 targeted (e.g. sunitinib,trastuzumab) therapies seldom cause myelosuppression. INFECTION Infe ...

372 CANCER CHEMOTHERAPY 3.DNA-binding agents; 4.topoisomerase inhibitors; 5.microtubular inhibitors (vinca alkaloids and taxanes ...

DRUGSUSED INCANCERCHEMOTHERAPY 373 doses are used to prepare patients with acute leukaemia or aplastic anaemia for allogeneic bo ...

374 CANCER CHEMOTHERAPY myelosuppression – usually thrombocytopenia; nervous system effects – cerebellar syndrome, peripheral n ...

DRUGSUSED INCANCERCHEMOTHERAPY 375 Adverse effects These include the following: myelosuppression; nausea and vomiting; stomatit ...

376 CANCER CHEMOTHERAPY Adverse effects Oral ulceration and diarrhoea is an adverse event in approximately 20% of patients. Bon ...

DRUGSUSED INCANCERCHEMOTHERAPY 377 patients who are concurrently taking allopurinol. This is important because allopurinolpretre ...

378 CANCER CHEMOTHERAPY Chronic: cardiomyopathy, leading to death in up to 60% of those who develop signs of congestive cardiac ...

DRUGSUSED INCANCERCHEMOTHERAPY 379 DNA TOPOISOMERASE II INHIBITORS A component of the cytotoxic action of anthracyclines (e.g. d ...

380 CANCER CHEMOTHERAPY Mechanism of action Paclitaxelbinds to the β-subunit of tubulin and antagonizes the depolymerization of ...

DRUGSUSED INCANCERCHEMOTHERAPY 381 Mechanism of action Imatinibis an ATP mimetic. It competitively inhibits several tyrosine kin ...

382 CANCER CHEMOTHERAPY MULTI-TARGETED TKIs Sorafenibandsunitinibare used in the USA as single oral agents to treat advanced ren ...

DRUGSUSED INCANCERCHEMOTHERAPY 383 acute hypersensitivity reactions; heart failure, especially in patients who have received pr ...

384 CANCER CHEMOTHERAPY OESTROGENS Oestrogens are little used in the current management of pro- static carcinoma, because of the ...

DRUGSUSED INCANCERCHEMOTHERAPY 385 INTERFERON-ALFA 2B Interferon-alfa 2b is a glycoprotein (molecular weight 15–27.6 kDa) produc ...

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PART X HAEMATOLOGY ...

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●Haematinics – iron, vitamin B 12 and folate 389 ●Haematopoietic growth factors 392 ●Coagulation factors and haemophilias A and ...