A Textbook of Clinical Pharmacology and Therapeutics

and is normally 54–80μmol/L. Transferrin saturation (i.e. plasma iron divided by TIBC) is normally 20–50% and pro- vides a usefu ...

bone marrow to produce red cells. The only advantages of parenteral iron are the following: Iron stores are rapidly and complet ...

glycoprotein of molecular weight approximately 55 kDa which forms a stable complex with vitamin B 12. The complex passes down th ...

produced by interstitial cells of the renal cortex adjacent to the proximal tubules and 10% by the liver. Biosynthesis is stimu- ...

Adverse effects These include the following: hypertension which can be severe; thrombosis, for example of shunts, or causing a ...

Therapeutic principles The extent of haemorrhage depends on the severity of the factor VIII or IX deficiency and the severity of ...

FURTHER READING Akkerman JW. Thrombopoietin and platelet function. Seminars in Thrombosis and Hemostasis2006; 32 : 295–304. Chon ...

PART XI IMMUNOPHARMACOLOGY ...

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●Introduction 399 ●Immunity and hypersensitivity 399 ●Immunosuppressive agents 400 ●Chemical mediators of the immune response an ...

TYPE-I HYPERSENSITIVITY This results from the combination of antigen with high- affinity IgE (reaginic) antibody on the surface ...

CALCINEURIN INHIBITORS:CICLOSPORIN (AND ITS CONGENERS) Ciclosporinis a cyclic hydrophobic decapeptide that was originally extrac ...

activity. This impairs access to the nucleus of the cytosolic component of the transcription promoter nuclear factor of activate ...

cardiac) transplantation and is a more effective alternative than azathioprine.Mycophenolate mofetilmay also be effective in the ...

Other humanized monoclonal antibodies used as immuno- suppressants include: Daclizumabandbasilixumab(organ transplant rejection ...

DRUGS THAT BLOCK THE EFFECTS OF MEDIATORS OF ALLERGY Therapeutic approaches to the management of allergic disease produced by me ...

antihistaminic actions are similar when used in clinically appro- priate dosage, but their major differences are in duration of ...

DRUGS THAT ENHANCE IMMUNE SYSTEM FUNCTION ADJUVANTS Adjuvants non-specifically augment the immune response when mixed with antig ...

hypogammaglobulinaemia and IgG subclass deficiency (e.g. Bruton’s agammaglobulinaemia, Wiskott–Aldrich syn- drome), idiopathic t ...

PART XII THE SKIN ...