A Textbook of Clinical Pharmacology and Therapeutics

350 FUNGAL AND NON-HIVVIRAL INFECTIONS Case history A 35-year-old female with schizophrenia and insulin-dependent diabetes melli ...

●Introduction 351 ●Immunopathogenesis of HIV-1 infection 351 ●General principles for treating HIV-seropositive individuals 352 ● ...

352 HIVANDAIDS (ELISA) techniques that identify HIV-1 antibodies and Western blotting is then used to confirm the presence of HI ...

ANTI-HIV DRUGS 353 specialist care. Current principles emphasize combination ther- apy, regime convenience, tolerability and lif ...

354 HIVANDAIDS Drug interactions These are numerous and clinically important; the following list is not comprehensive: probenec ...

NON-NUCLEOSIDE ANALOGUE REVERSE TRANSCRIPTASE INHIBITORS The non-nucleoside analogue reverse transcriptase inhibitors (NNRTIs) a ...

356 HIVANDAIDS Pharmacokinetics Lopinavir is well absorbed with food and 98–99% protein bound (albumin and alpha-1-acid glycopro ...

OPPORTUNISTICINFECTIONS INHIV-1-SEROPOSITIVEPATIENTS 357 FUSION INHIBITORS Uses Currently, enfuvirtide is the only available HIV ...

358 HIVANDAIDS Adverse effects The adverse effects of the nebulized route include cough and bronchospasm, pre-administration of ...

salvage therapy include azithromycin or clarithromycin (Chapter 43) and atovaquone. MYCOBACTERIUM TUBERCULOSISTHERAPY IN HIV PAT ...

FURTHER READING AND WEB MATERIAL Dybul M, Fauci AS, Bartlett JG et al. Panel on Clinical Practices for Treatment of HIV. Guideli ...

●Malaria 361 ●Trypanosomal infection 364 ●Helminthic infection 364 CHAPTER 47 47 Malaria and other parasitic infections PARASITI ...

362 MALARIA AND OTHER PARASITIC INFECTIONS MALARIA PROPHYLAXIS Malaria prophylaxis is relative and the agents are chosen mainly ...

MALARIA 363 Pharmacokinetics Chloroquineis rapidly and well absorbed from the intestine. It is approximately 50% bound to plasma ...

364 MALARIA AND OTHER PARASITIC INFECTIONS 8-AMINOQUINOLINES (PRIMAQUINE) Primaquineis used to eradicate the hepatic forms of P. ...

HELMINTHICINFECTION 365 Table 47.2:Drug therapy of non-malarial protozoan infections Protozoan species Drug therapy Additional c ...

FURTHER READING Bradley DJ, Bannister B, on behalf of the Health Protection Agency Advisory Committee on Malaria Prevention for ...

●Introduction 367 ●Pathophysiology of neoplastic cell growth 367 ●Cytotoxic therapy: general principles 367 ●Resistance to cytot ...

368 CANCER CHEMOTHERAPY several malignancies, especially lymphomas and leukaemias. There are two main groups of cytotoxic drugs, ...

COMMONCOMPLICATIONS OFCANCERCHEMOTHERAPY 369 Cytotoxic cancer chemotherapy is primarily used to induce and maintain a remission ...