A Textbook of Clinical Pharmacology and Therapeutics

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●Introduction 411 ●Acne 411 ●Alopecia and hirsutism 412 ●Dermatitis (eczema) 413 ●Psoriasis 414 ●Urticaria 416 ●Superficial bact ...

ISOTRETINOIN Uses Isotretinoinis the D-isomer of tretinoin, another vitamin A analogue. It is given orally for severe acne or ro ...

DERMATITIS (ECZEMA) PRINCIPLES OF TREATMENT The most common forms of dermatitis that present to physi- cians are atopic dermatit ...

Uses The use of systemic glucocorticosteroids (e.g. oral prednisolone) is limited to serious disorders such as pemphigus or refr ...

PSORIASIS 415 Emollients Improving? Continue as necessary Yes Yes Yes No No No Salicylic acid topically, or Coal tar topically, ...

UVA light, notably optimization of the dose regimen, have reduced the risk of carcinogenicity. Phototherapy combined with coal t ...

TREATMENT OF OTHER SKIN INFECTIONS (LICE, SCABIES) The treatment of lice and scabies is covered in Table 51.5. ADVERSE DRUG REAC ...

418 DRUGS AND THE SKIN Table 51.6:Adverse effects of drugs on the skin Cutaneous eruption Drugs commonly associated Comment Acne ...

effect of too high a dose of UVB in a subject who has been exposed to a drug. The reaction is like severe sunburn and the thresh ...

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PART XIII THE EYE ...

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●Introduction: ocular anatomy, physiology and biochemistry 423 ●General pharmacokinetics of intra-ocular drug administration 423 ...

424 DRUGS AND THE EYE Posterior cavity (vitreous humour) Retinal arteries and veins Macula lutea Central fovea (II) nerve Optic ...

to cause pupillary dilatation, namely muscarinic antagonists (anticholinergics) and sympathomimetics. Short-acting relatively we ...

Chronic simple glaucoma is due to a limitation of flow through the trabecular meshwork. Initial treatment is with a top- icalβ-b ...

DRUGS USED TO TREAT EYE INFECTIONS Several antimicrobial agents are formulated for ophthalmic use (see Tables 52.3 and 52.4). Ap ...

Sodium cromoglicateor nedocromildrops are widely used in the longer-term treatment of allergic conjunctivitis. Sodium cromoglica ...

CONTACT LENS WEARERS As the number of patients who wear contact lenses increases, an awareness has developed that these patients ...