A Textbook of Clinical Pharmacology and Therapeutics

450 DRUG OVERDOSE AND POISONING FURTHER READING Afshari R, Good AM, Maxwell SRJ. Co-proxamol overdose is associ- ated with a 10- ...

phase 15 ‘ABCD’ rule, antihypertensive drugs 187 abciximab 93, 209 Aberdeen–Dundee intensive monitoring system 65 ablation thera ...

aminophylline 238 plasma concentration monitoring 43 4-aminoquinolines 362–3 8-aminoquinolines 364 aminosalicylates 255 amiodaro ...

atrial fibrillation 217, 221 digoxin 215 atrial flutter 217, 221 atrioventricular block 217, 223 atropine 226–7 cardiopulmonary ...

carteolol 429 carvedilol 214 case-control studies, adverse drug reactions 65 caspofungin 343–4 catecholO-methyltransferase inhib ...

Cushing’s syndrome 302 cyclic adenosine monophosphate (cAMP)  2 -adrenoceptor agonists on 236–7 lithium on 121 Parkinson’s synd ...

drug-eluting stents 197 drug interactions 71–8 alcohol 442 antacids 249 anticonvulsants 139, 141 benzodiazepines 108 enzyme indu ...

5-fluorouracil 375–6 fluoxetine, monoamine oxidase inhibitors and 118 flutamide 384 fluticasone 240 folate 392 antagonism in mal ...

hepatotoxicity 69, 262, 263 halothane 146, 147 non-steroidal anti-inflammatory drugs 169 rifampicin 336 see alsoparacetamol hepc ...

children 54 diazepam 108 iron preparations 390–1 phenytoin 137 intrinsic factor 391–2 iodine 292–3 radioactive 294–5 ion-exchang ...

meperidineseepethidine 6-mercaptopurine 79, 84, 376–7 allopurinol and 173, 376–7 meropenem 327 mesalazine 19, 255 mesna 373 meta ...

non-steroidal anti-inflammatory drugs 167–9 asthma 168–9, 243 elderly patients 60 eye 427 hyperkalaemia 280 methotrexate and 375 ...

pharmacokinetics (Contd) non-linear 15–16 first-pass metabolism 29 phenytoin 16, 136–7 placenta 45 pregnancy 47 renal disease 35 ...

puberty (male), delay 314 puerperium, anticoagulants 209 pulmonary blood flow, anaesthesia 146 pulmonary embolism, heparins for ...

sodium ketoacidosis 287 laxative abuse 258 lithium and 122 liver disease 38 see alsovolume overload sodium bicarbonate as antaci ...

tolerance 9, 433 benzodiazepines 108 nitrates 200, 201 opioids 160, 435–6 tonic–clonic seizures, drugs for 134 topiramate 138 mi ...